The domain within your query sequence starts at position 2619 and ends at position 2672; the E-value for the KU domain shown below is 2.1e-26.

DICKLSRDAGTCVDFKLLWHYDLESKSCKRFWYGGCGGNENRFHSQEECEKMCS

KU

BPTI/Kunitz family of serine protease inhibitors.

• SMART accession number: SM00131
• Description: Serine protease inhibitors. One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein.
• Interpro abstract (IPR002223):

  The majority of the sequences having this domain belong to the MEROPS inhibitor family I2, clan IB; the Kunitz/bovine pancreatic trypsin inhibitor family, they inhibit proteases of the S1 family [ (PUBMED:14705960) ] and are restricted to the metazoa with a single exception: Amsacta moorei entomopoxvirus. They are short (~50 residue) alpha/beta proteins with few secondary structures. The fold is constrained by 3 disulphide bonds. The type example for this family is aprotinin (bovine pancreatic trypsin inhibitor) [ (PUBMED:1714504) ] (or basic protease inhibitor), but the family includes numerous other members [ (PUBMED:1703675) (PUBMED:1593645) (PUBMED:8159751) (PUBMED:1304909) ], such as snake venom basic protease; mammalian inter-alpha-trypsin inhibitors; trypstatin, a rodent mast cell inhibitor of trypsin; a domain found in an alternatively-spliced form of Alzheimer's amyloid beta-protein; domains at the C-termini of the alpha(1) and alpha(3) chains of type VII and type VI collagens; and tissue factor pathway inhibitor precursor.

  The pancreatic trypsin inhibitor (Kunitz) family [ (PUBMED:6996568) (PUBMED:1703675) (PUBMED:1593645) ] is one of the numerous families of serine proteinase inhibitors. The basic structure of such a type of inhibitor is shown in the following schematic representation:

              +-----------------------+
              |  +--------+           |
              |  |      **|*******    |
            xxCxxC#xxxCxxxCxxxxxxCxxxxCxx
                      |          |
                      +----------+
  
              {------50 residues------}
  
  'C': conserved cysteine involved in a disulfide bond.
  '#': active site residue.
  '*': position of the pattern.
  

• GO function: serine-type endopeptidase inhibitor activity (GO:0004867)

There are 33749 KU domains in 16023 proteins in SMART's nrdb database.

Literature (relevant references for this domain)

Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

• Salier JP
• Inter-alpha-trypsin inhibitor: emergence of a family within the Kunitz-type protease inhibitor superfamily.
• Trends Biochem Sci. 1990; 15: 435-9

Plasma inter-alpha-trypsin inhibitor (I alpha TI) is a major representative of the superfamily of Kunitz-type protease inhibitors in mammals. Formerly, I alpha TI was considered to be a single polypeptide, but recent molecular genetic studies have demonstrated an unexpected multipolypeptide chain structure. The newly discovered genes and gene products form the basis of a new family of I alpha TI-related protease inhibitors.

• Ponte P et al.
• A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors.
• Nature. 1988; 331: 525-7

The amyloid proteins isolated from neuritic plaques and the cerebrovasculature of Alzheimer's disease are self-aggregating moieties termed A4 protein and beta-protein, respectively. A putative A4 amyloid precursor (herein termed A4(695] has been characterized by analysis of a human brain complementary DNA. We report here the sequence of a closely related amyloid cDNA, A4(751), distinguished from A4(695) by the presence of a 168 base-pair (bp) sequence which adds 57 amino acids to, and removes one residue from, the predicted A4(695) protein. The peptide predicted from this insert is very similar to the Kunitz family of serine proteinase inhibitors. The two A4-specific messenger RNAs are differentially expressed: in a limited survey, A4(751) mRNA appears to be ubiquitous, whereas A4(695) mRNA has a restricted pattern of expression which includes cells from neuronal tissue. These data may have significant implications for understanding amyloid deposition in Alzheimer's disease.

• Tanzi RE, McClatchey AI, Lamperti ED, Villa-Komaroff L, Gusella JF, Neve RL
• Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease.
• Nature. 1988; 331: 528-30

Amyloid B-protein/amyloid A4 is a peptide present in the neuritic plaques, neurofibrillary tangles and cerebrovascular deposits in patients with Alzheimer's disease and Down's syndrome (trisomy 21) and may be involved in the pathogenesis of Alzheimer's disease. Recent molecular genetic studies have indicated that amyloid protein is encoded as part of a larger protein by a gene on human chromosome 21 (refs 6-9). The amyloid protein precursor (APP) gene is expressed in brain and in several peripheral tissues, but the specific biochemical events leading to deposition of amyloid are not known. We have now screened complementary DNA libraries constructed from peripheral tissues to determine whether the messenger RNA encoding APP in these tissues is identical to that expressed in brain, and we identify a second APP mRNA that encodes an additional internal domain with a sequence characteristic of a Kunitz-type serine protease inhibitor. The alternative APP mRNA is present in both brain and peripheral tissues of normal individuals and those with Alzheimer's disease, but its pattern of expression differs from that of the previously reported APP mRNA.

• LaskowskiMJ r, Kato I
• Protein inhibitors of proteinases.
• Annu Rev Biochem. 1980; 49: 593-626

Metabolism (metabolic pathways involving proteins which contain this domain)

% proteins involved	KEGG pathway ID	Description
34.48	map05010	Alzheimer's disease
24.14	map04610	Complement and coagulation cascades
20.69	map04512	ECM-receptor interaction
20.69	map04510	Focal adhesion

This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with KU domain which could be assigned to a KEGG orthologous group, and not all proteins containing KU domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

Structure (3D structures containing this domain)

3D Structures of KU domains in PDB

PDB code	Title
1aal	STRUCTURAL EFFECTS INDUCED BY MUTAGENESIS AFFECTED BY CRYSTAL PACKING FACTORS: THE STRUCTURE OF A 30-51 DISULFIDE MUTANT OF BASIC PANCREATIC TRYPSIN INHIBITOR
1aap	X-RAY CRYSTAL STRUCTURE OF THE PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR
1adz	THE SOLUTION STRUCTURE OF THE SECOND KUNITZ DOMAIN OF TISSUE FACTOR PATHWAY INHIBITOR, NMR, 30 STRUCTURES
1b0c	EVIDENCE OF A COMMON DECAMER IN THREE CRYSTAL STRUCTURES OF BPTI, CRYSTALLIZED FROM THIOCYANATE, CHLORIDE OR SULFATE
1bf0	CALCICLUDINE (CAC) FROM GREEN MAMBA DENDROASPIS ANGUSTICEPS, NMR, 15 STRUCTURES
1bhc	BOVINE PANCREATIC TRYPSIN INHIBITOR CRYSTALLIZED FROM THIOCYANATE
1bik	X-RAY STRUCTURE OF BIKUNIN FROM THE HUMAN INTER-ALPHA-INHIBITOR COMPLEX
1bpi	THE STRUCTURE OF BOVINE PANCREATIC TRYPSIN INHIBITOR AT 125K: DEFINITION OF CARBOXYL-TERMINAL RESIDUES GLYCINE-57 AND ALANINE-58
1bpt	CREVICE-FORMING MUTANTS OF BPTI: CRYSTAL STRUCTURES OF F22A, Y23A, N43G, AND F45A
1brb	CRYSTAL STRUCTURES OF RAT ANIONIC TRYPSIN COMPLEXED WITH THE PROTEIN INHIBITORS APPI AND BPTI
1brc	RELOCATING A NEGATIVE CHARGE IN THE BINDING POCKET OF TRYPSIN
1bth	STRUCTURE OF THROMBIN COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR
1bti	CREVICE-FORMING MUTANTS IN THE RIGID CORE OF BOVINE PANCREATIC TRYPSIN INHIBITOR: CRYSTAL STRUCTURES OF F22A, Y23A, N43G, AND F45A
1bun	STRUCTURE OF BETA2-BUNGAROTOXIN: POTASSIUM CHANNEL BINDING BY KUNITZ MODULES AND TARGETED PHOSPHOLIPASE ACTION
1bz5	EVIDENCE OF A COMMON DECAMER IN THREE CRYSTAL STRUCTURES OF BPTI, CRYSTALLIZE FROM THIOCYANATE, CHLORIDE OR SULFATE
1bzx	THE CRYSTAL STRUCTURE OF ANIONIC SALMON TRYPSIN IN COMPLEX WITH BOVINE PANCREATIC TRYPSIN INHIBITOR
1ca0	BOVINE CHYMOTRYPSIN COMPLEXED TO APPI
1cbw	BOVINE CHYMOTRYPSIN COMPLEXED TO BPTI
1co7	R117H mutant rat anionic trypsin complexed with bovine pancreatic trypsin inhibitor (BPTI)
1d0d	CRYSTAL STRUCTURE OF TICK ANTICOAGULANT PROTEIN COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR
1dem	PROTEINASE INHIBITOR HOMOLOGUES AS POTASSIUM CHANNEL BLOCKERS
1den	PROTEINASE INHIBITOR HOMOLOGUES AS POTASSIUM CHANNEL BLOCKERS
1dtk	THE NMR SOLUTION STRUCTURE OF DENDROTOXIN K FROM THE VENOM OF DENDROASPIS POLYLEPIS POLYLEPIS
1dtx	CRYSTAL STRUCTURE OF ALPHA-DENDROTOXIN FROM THE GREEN MAMBA VENOM AND ITS COMPARISON WITH THE STRUCTURE OF BOVINE PANCREATIC TRYPSIN INHIBITOR
1eaw	Crystal structure of the MTSP1 (matriptase)-BPTI (aprotinin) complex
1ejm	CRYSTAL STRUCTURE OF THE BPTI ALA16LEU MUTANT IN COMPLEX WITH BOVINE TRYPSIN
1f5r	RAT TRYPSINOGEN MUTANT COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR
1f7z	RAT TRYPSINOGEN K15A COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR
1fak	HUMAN TISSUE FACTOR COMPLEXED WITH COAGULATION FACTOR VIIA INHIBITED WITH A BPTI-MUTANT
1fan	CREVICE-FORMING MUTANTS IN THE RIGID CORE OF BOVINE PANCREATIC TRYPSIN INHIBITOR: CRYSTAL STRUCTURES OF F22A, Y23A, N43G, AND F45A
1fy8	CRYSTAL STRUCTURE OF THE DELTAILE16VAL17 RAT ANIONIC TRYPSINOGEN-BPTI COMPLEX
1g6x	ULTRA HIGH RESOLUTION STRUCTURE OF BOVINE PANCREATIC TRYPSIN INHIBITOR (BPTI) MUTANT WITH ALTERED BINDING LOOP SEQUENCE
1irh	The Solution Structure of The Third Kunitz Domain of Tissue Factor Pathway Inhibitor
1jc6	SOLUTION STRUCTURE OF BUNGARUS FACIATUS IX, A KUNITZ-TYPE CHYMOTRYPSIN INHIBITOR
1jv8	NMR Structure of BPTI Mutant G37A
1jv9	NMR Structure of BPTI Mutant G37A
1k6u	Crystal Structure of Cyclic Bovine Pancreatic Trypsin Inhibitor
1knt	THE 1.6 ANGSTROMS STRUCTURE OF THE KUNITZ-TYPE DOMAIN FROM THE ALPHA3 CHAIN OF THE HUMAN TYPE VI COLLAGEN
1kth	The Anisotropic Refinement Of Kunitz Type Domain C5 at 0.95 Angstrom
1kun	SOLUTION STRUCTURE OF THE HUMAN ALPHA3-CHAIN TYPE VI COLLAGEN C-TERMINAL KUNITZ DOMAIN, NMR, 20 STRUCTURES
1ld5	STRUCTURE OF BPTI MUTANT A16V
1ld6	STRUCTURE OF BPTI_8A MUTANT
1mtn	BOVINE ALPHA-CHYMOTRYPSIN:BPTI CRYSTALLIZATION
1nag	CREVICE-FORMING MUTANTS IN THE RIGID CORE OF BOVINE PANCREATIC TRYPSIN INHIBITOR: CRYSTAL STRUCTURES OF F22A, Y23A, N43G, AND F45A
1oa5	The solution structure of bovine pancreatic trypsin inhibitor at high pressure
1oa6	The solution structure of bovine pancreatic trypsin inhibitor at high pressure
1p2i	Structural consequences of accommodation of four non-cognate amino-acid residues in the S1 pocket of bovine trypsin and chymotrypsin
1p2j	Structural consequences of accommodation of four non-cognate amino-acid residues in the S1 pocket of bovine trypsin and chymotrypsin
1p2k	Structural consequences of accommodation of four non-cognate amino-acid residues in the S1 pocket of bovine trypsin and chymotrypsin
1p2m	Structural consequences of accommodation of four non-cognate amino-acid residues in the S1 pocket of bovine trypsin and chymotrypsin
1p2n	Structural consequences of accommodation of four non-cognate amino-acid residues in the S1 pocket of bovine trypsin and chymotrypsin
1p2o	Structural consequences of accommodation of four non-cognate amino-acid residues in the S1 pocket of bovine trypsin and chymotrypsin
1p2q	Structural consequences of accommodation of four non-cognate amino-acid residues in the S1 pocket of bovine trypsin and chymotrypsin
1pit	DETERMINATION OF A HIGH-QUALITY NUCLEAR MAGNETIC RESONANCE SOLUTION STRUCTURE OF THE BOVINE PANCREATIC TRYPSIN INHIBITOR AND COMPARISON WITH THREE CRYSTAL STRUCTURES
1qlq	BOVINE PANCREATIC TRYPSIN INHIBITOR (BPTI) MUTANT WITH ALTERED BINDING LOOP SEQUENCE
1shp	THE NMR SOLUTION STRUCTURE OF A KUNITZ-TYPE PROTEINASE INHIBITOR FROM THE SEA ANEMONE STICHODACTYLA HELIANTHUS
1t7c	CRYSTAL STRUCTURE OF THE P1 GLU BPTI MUTANT- BOVINE CHYMOTRYPSIN COMPLEX
1t8l	CRYSTAL STRUCTURE OF THE P1 MET BPTI MUTANT- BOVINE CHYMOTRYPSIN COMPLEX
1t8m	CRYSTAL STRUCTURE OF THE P1 HIS BPTI MUTANT- BOVINE CHYMOTRYPSIN COMPLEX
1t8n	CRYSTAL STRUCTURE OF THE P1 THR BPTI MUTANT- BOVINE CHYMOTRYPSIN COMPLEX
1t8o	CRYSTAL STRUCTURE OF THE P1 TRP BPTI MUTANT- BOVINE CHYMOTRYPSIN COMPLEX
1taw	BOVINE TRYPSIN COMPLEXED TO APPI
1tfx	COMPLEX OF THE SECOND KUNITZ DOMAIN OF TISSUE FACTOR PATHWAY INHIBITOR WITH PORCINE TRYPSIN
1toc	STRUCTURE OF SERINE PROTEINASE
1tpa	THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS
1uua	Solution structure of a truncated bovine pancreatic trypsin inhibitor, 3-58 BPTI
1uub	Solution structure of a truncated bovine pancreatic trypsin inhibitor mutant, 3-58 BPTI (K15R, R17A, R42S)
1y62	A 2.4 crystal structure of conkunitzin-S1, a novel Kunitz-fold cone snail neurotoxin.
1yc0	short form HGFA with first Kunitz domain from HAI-1
1ykt	Trypsin/Bpti complex mutant
1ylc	Trypsin/BPTI complex mutant
1yld	Trypsin/BPTI complex mutant
1zjd	Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with Kunitz Protease Inhibitor Domain of Protease Nexin II
1zr0	Crystal Structure of Kunitz Domain 1 of Tissue Factor Pathway Inhibitor-2 with Bovine Trypsin
2ca7	Conkunitzin-S1 Is The First Member Of A New Kunitz-Type Neurotoxin Family- Structural and Functional Characterization
2ddi	NMR structure of the second Kunitz domain of human WFIKKN1
2ddj	NMR structure of the second Kunitz domain of human WFIKKN1
2fi3	Crystal structure of a BPTI variant (Cys14->Ser, Cys38->Ser) in complex with trypsin
2fi4	Crystal structure of a BPTI variant (Cys14->Ser) in complex with trypsin
2fi5	Crystal structure of a BPTI variant (Cys38->Ser) in complex with trypsin
2ftl	Crystal structure of trypsin complexed with BPTI at 100K
2ftm	Crystal structure of trypsin complexed with the BPTI variant (Tyr35->Gly)
2hex	DECAMERS OBSERVED IN THE CRYSTALS OF BOVINE PANCREATIC TRYPSIN INHIBITOR
2ijo	Crystal Structure of the West Nile virus NS2B-NS3 protease complexed with bovine pancreatic trypsin inhibitor
2j6d	CONKUNITZIN-S2 - CONE SNAIL NEUROTOXIN - DENOVO STRUCTURE
2jot	Nuclear Magnetic Resonance Studies on Huwentoxin-XI from the Chinese Bird Spider Ornithoctonus huwena
2kai	REFINED 2.5 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF THE COMPLEX FORMED BY PORCINE KALLIKREIN A AND THE BOVINE PANCREATIC TRYPSIN INHIBITOR. CRYSTALLIZATION, PATTERSON SEARCH, STRUCTURE DETERMINATION, REFINEMENT, STRUCTURE AND COMPARISON WITH ITS COMPONENTS AND WITH THE BOVINE TRYPSIN-PANCREATIC TRYPSIN INHIBITOR COMPLEX
2kcr	Solution structure of anntoxin
2knt	THE 1.2 ANGSTROM STRUCTURE OF KUNITZ TYPE DOMAIN C5
2m01	Solution structure of Kunitz-type neurotoxin LmKKT-1a from scorpion venom
2m99	Solution structure of a chymotrypsin inhibitor from the Taiwan cobra
2ody	Thrombin-bound boophilin displays a functional and accessible reactive-site loop
2ptc	THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS
2r9p	Human mesotrypsin complexed with bovine pancreatic trypsin inhibitor(BPTI)
2ra3	Human cationic trypsin complexed with bovine pancreatic trypsin inhibitor (BPTI)
2tgp	THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS
2tpi	ON THE DISORDERED ACTIVATION DOMAIN IN TRYPSINOGEN. CHEMICAL LABELLING AND LOW-TEMPERATURE CRYSTALLOGRAPHY
2w8x	Structure of the tick ion-channel modulator Ra-KLP
2zjx	Bovine pancreatic trypsin inhibitor (BPTI) containing only the [5,55] disulfide bond
2zvx	Structure of a BPTI-[5,55] variant containing Gly/Val at the 14/38th positions
3aub	A simplified BPTI variant stabilized by the A14G and A38V substitutions
3auc	A simplified BPTI variant with poly SER (C5S) amino acid tag at the c-terminus
3aud	Simplified BPTI variant with poly Asn amino acid tag (C5N) at the C-terminus
3aue	A simplified BPTI variant with poly His amino acid tag (C5H) at the C-terminus
3aug	A simplified BPTI variant with poly Pro amino acid tag (C5P) at the C-terminus
3auh	A simplified BPTI variant with poly Arg amino acid tag (C3R) at the C-terminus
3aui	A simplified BPTI variant with poly Glu amino acid tag (C3E) at the C-terminus
3btd	The Crystal Structures of the Complexes Between the Bovine Beta-Trypsin and Ten P1 Variants of BPTI.
3bte	The Crystal Structures of the Complexes Between Bovine Beta-Trypsin and Ten P1 Variants of BPTI.
3btf	THE CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN BOVINE BETA-TRYPSIN AND TEN P1 VARIANTS OF BPTI.
3btg	THE CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN BOVINE BETA-TRYPSIN AND TEN P1 VARIANTS OF BPTI
3bth	THE CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN BOVINE BETA-TRYPSIN AND TEN P1 VARIANTS OF BPTI
3btk	THE CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN BOVINE BETA-TRYPSIN AND TEN P1 VARIANTS OF BPTI
3btm	THE CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN BOVINE BETA-TRYPSIN AND TEN P1 VARIANTS OF BPTI
3btq	THE CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN BOVINE BETA-TRYPSIN AND TEN P1 VARIANTS OF BPTI
3btt	THE CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN BOVINE BETA-TRYPSIN AND TEN P1 VARIANTS OF BPTI
3btw	THE CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN BOVINE BETA-TRYPSIN AND TEN P1 VARIANTS OF BPTI
3byb	Crystal structure of Textilinin-1, a Kunitz-type serine protease inhibitor from the Australian Common Brown snake venom
3ci7	Crystal structure of a simplified BPTI containing 20 alanines
3d65	Crystal structure of Textilinin-1, a Kunitz-type serine protease inhibitor from the Australian Common Brown snake venom, in complex with trypsin
3fp6	Anionic trypsin in complex with bovine pancreatic trypsin inhibitor (BPTI) determined to the 1.49 A resolution limit
3fp7	Anionic trypsin variant S195A in complex with bovine pancreatic trypsin inhibitor (BPTI) cleaved at the scissile bond (LYS15-ALA16) determined to the 1.46 A resolution limit
3fp8	Anionic trypsin variant S195A in complex with bovine pancreatic trypsin inhibitor (BPTI) determined to the 1.46 A resolution limit
3gym	Structure of Prostasin in Complex with Aprotinin
3l33	Human mesotrypsin complexed with amyloid precursor protein inhibitor(APPI)
3l3t	Human mesotrypsin complexed with amyloid precursor protein inhibitor variant (APPIR15K)
3ldi	Crystal structure of aprotinin in complex with sucrose octasulfate: unusual interactions and implication for heparin binding
3ldj	Crystal structure of aprotinin in complex with sucrose octasulfate: unusual interactions and implication for heparin binding
3ldm	Crystal structure of aprotinin in complex with sucrose octasulfate: unusual interactions and implication for heparin binding
3m7q	Crystal structure of recombinant Kunitz Type serine protease Inhibitor-1 from the Caribbean sea anemone stichodactyla helianthus in complex with bovine pancreatic trypsin
3ofw	Crystal structure of recombinant Kunitz Type serine protease Inhibitor-1 from the Carribean sea anemone stichodactyla helianthus
3otj	A Crystal Structure of Trypsin Complexed with BPTI (Bovine Pancreatic Trypsin Inhibitor) by X-ray/Neutron Joint Refinement
3p92	Human mesotrypsin complexed with bovine pancreatic trypsin inhibitor variant (BPTI-K15R/R17G)
3p95	Human mesotrypsin complexed with bovine pancreatic trypsin inhibitor variant (BPTI-K15R/R17D)
3t62	Crystal structure of recombinant Kunitz Type serine protease Inhibitor-1 from the Caribbean Sea anemone Stichodactyla helianthus in complex with bovine chymotrypsin
3tgi	WILD-TYPE RAT ANIONIC TRYPSIN COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR (BPTI)
3tgj	S195A TRYPSINOGEN COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR (BPTI)
3tgk	TRYPSINOGEN MUTANT D194N AND DELETION OF ILE 16-VAL 17 COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR (BPTI)
3tpi	THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS
3u1j	Aprotinin bound to Dengue virus protease
3uir	Crystal structure of the plasmin-textilinin-1 complex
3uou	Crystal structure of the Kunitz-type protease inhibitor ShPI-1 Lys13Leu mutant in complex with pancreatic elastase
3wny	3WNY
4bd9	Structure of the complex between SmCI and human carboxypeptidase A4
4bnr	Extremely stable complex of crayfish trypsin with bovine trypsin inhibitor
4bqd	KD1 of human TFPI in complex with a synthetic peptide
4dg4	Human mesotrypsin-S39Y complexed with bovine pancreatic trypsin inhibitor (BPTI)
4dtg	Hemostatic effect of a monoclonal antibody mAb 2021 blocking the interaction between FXa and TFPI in a rabbit hemophilia model
4isl	Crystal Structure of the inactive Matriptase in complex with its inhibitor HAI-1
4isn	Crystal Structure of Matriptase in complex with its inhibitor HAI-1
4iso	Crystal Structure of Matriptase in complex with its inhibitor HAI-1
4ntw	Structure of acid-sensing ion channel in complex with snake toxin
4ntx	Structure of acid-sensing ion channel in complex with snake toxin and amiloride
4nty	Cesium sites in the crystal structure of acid-sensing ion channel in complex with snake toxin
4pti	THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS
4tpi	THE REFINED 2.2-ANGSTROMS (0.22-NM) X-RAY CRYSTAL STRUCTURE OF THE TERNARY COMPLEX FORMED BY BOVINE TRYPSINOGEN, VALINE-VALINE AND THE ARG15 ANALOGUE OF BOVINE PANCREATIC TRYPSIN INHIBITOR
4u30	4U30
4u32	4U32
4wwy	4WWY
4wxv	4WXV
4y0y	4Y0Y
4y0z	4Y0Z
4y10	4Y10
4y11	4Y11
5c67	5C67
5ezd	5EZD
5jbt	5JBT
5pti	STRUCTURE OF BOVINE PANCREATIC TRYPSIN INHIBITOR. RESULTS OF JOINT NEUTRON AND X-RAY REFINEMENT OF CRYSTAL FORM II
6pti	STRUCTURE OF FORM III CRYSTALS OF BOVINE PANCREATIC TRYPSIN INHIBITOR
7pti	STRUCTURAL EFFECTS INDUCED BY REMOVAL OF A DISULFIDE BRIDGE. THE X-RAY STRUCTURE OF THE C30A(SLASH)C51A MUTANT OF BASIC PANCREATIC TRYPSIN INHIBITOR AT 1.6 ANGSTROMS
8pti	CRYSTAL STRUCTURE OF A Y35G MUTANT OF BOVINE PANCREATIC TRYPSIN INHIBITOR
9pti	BASIC PANCREATIC TRYPSIN INHIBITOR (MET 52 OXIDIZED)

Links (links to other resources describing this domain)

• PROSITE: KU_DOMAIN
• PFAM: Kunitz_BPTI
• INTERPRO: IPR002223