The domain within your query sequence starts at position 515 and ends at position 556; the E-value for the Kelch domain shown below is 3.06e-4.

HIYVVGGAMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNN

Kelch

• SMART accession number: SM00612
• Description: -
• Interpro abstract (IPR006652):

  Kelch is a 50-residue motif, named after the Drosophila mutant in which it was first identified [ (PUBMED:8453663) ]. This sequence motif represents one beta-sheet blade, and several of these repeats can associate to form a beta-propeller. For instance, the motif appears 6 times in Drosophila egg-chamber regulatory protein (also known as ring canal kelch protein), creating a 6-bladed beta-propeller. The motif is also found in mouse protein MIPP [ (PUBMED:8453663) ] and in a number of poxviruses. In addition, kelch repeats have been recognised in alpha- and beta-scruin [ (PUBMED:7593276) (PUBMED:7822422) ], and in galactose oxidase from the fungus Dactylium dendroides [ (PUBMED:8126718) (PUBMED:2002850) ]. The structure of galactose oxidase reveals that the repeated sequence corresponds to a 4-stranded anti-parallel beta-sheet motif that forms the repeat unit in a super-barrel structural fold [ (PUBMED:8182749) ].

  The known functions of kelch-containing proteins are diverse: scruin is an actin cross-linking protein; galactose oxidase catalyses the oxidation of the hydroxyl group at the C6 position in D-galactose; and kelch may have a cytoskeletal function, as it is localised to the actin-rich ring canals that connect the 15 nurse cells to the developing oocyte in Drosophila [ (PUBMED:7593276) ]. Nevertheless, based on the location of the kelch pattern in the catalytic unit in galactose oxidase, functionally important residues have been predicted in glyoxal oxidase [ (PUBMED:8126718) ].

  This entry represents a type of kelch sequence motif that comprises one beta-sheet blade.

• GO function: protein binding (GO:0005515)

There are 151337 Kelch domains in 35376 proteins in SMART's nrdb database.

Metabolism (metabolic pathways involving proteins which contain this domain)

% proteins involved	KEGG pathway ID	Description
90.00	map04120	Ubiquitin mediated proteolysis
5.00	map00020	Citrate cycle (TCA cycle)
5.00	map00720	Reductive carboxylate cycle (CO2 fixation)

This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with Kelch domain which could be assigned to a KEGG orthologous group, and not all proteins containing Kelch domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

Structure (3D structures containing this domain)

3D Structures of Kelch domains in PDB

PDB code	Title
1gof	NOVEL THIOETHER BOND REVEALED BY A 1.7 ANGSTROMS CRYSTAL STRUCTURE OF GALACTOSE OXIDASE
1gog	NOVEL THIOETHER BOND REVEALED BY A 1.7 ANGSTROMS CRYSTAL STRUCTURE OF GALACTOSE OXIDASE
1goh	NOVEL THIOETHER BOND REVEALED BY A 1.7 ANGSTROMS CRYSTAL STRUCTURE OF GALACTOSE OXIDASE
1k3i	Crystal Structure of the Precursor of Galactose Oxidase
1t2x	Glactose oxidase C383S mutant identified by directed evolution
1u6d	Crystal structure of the Kelch domain of human Keap1
1x2j	Structural basis for the defects of human lung cancer somatic mutations in the repression activity of Keap1 on Nrf2
1x2r	Structural basis for the defects of human lung cancer somatic mutations in the repression activity of Keap1 on Nrf2
1zgk	1.35 angstrom structure of the Kelch domain of Keap1
2dyh	Crystal structure of the Keap1 protein in complexed with the N-terminal region of the Nrf2 transcription factor
2eib	Crystal Structure of Galactose Oxidase, W290H mutant
2eic	Crystal Structure of Galactose Oxidase mutant W290F
2eid	Galactose Oxidase W290G mutant
2eie	Crystal Structure of Galactose Oxidase complexed with Azide
2flu	Crystal Structure of the Kelch-Neh2 Complex
2jkx	Galactose oxidase. MatGO. Copper free, expressed in Pichia Pastoris.
2vpj	Crystal structure of the Kelch domain of human KLHL12
2vz1	Premat-galactose oxidase
2vz3	bleached galactose oxidase
2woz	The novel beta-propeller of the BTB-Kelch protein Krp1 provides the binding site for Lasp-1 that is necessary for pseudopodia extension
2wq8	Glycan labelling using engineered variants of galactose oxidase obtained by directed evolution
2xn4	Crystal structure of the kelch domain of human KLHL2 (Mayven)
2z32	Crystal structure of Keap1 complexed with Prothymosin alpha
2zw9	Crystal structure of tRNA wybutosine synthesizing enzyme TYW4
2zwa	Crystal structure of tRNA wybutosine synthesizing enzyme TYW4
2zzk	Crystal structure of tRNA wybutosine synthesizing enzyme TYW4
3ade	Crystal Structure of Keap1 in Complex with Sequestosome-1/p62
3ii7	Crystal structure of the kelch domain of human KLHL7
3vng	Crystal Structure of Keap1 in Complex with Synthetic Small Molecular based on a co-crystallization
3vnh	Crystal Structure of Keap1 Soaked with Synthetic Small Molecular
3wdz	Crystal Structure of Keap1 in Complex with phosphorylated p62
3wn7	Crystal Structure of Keap1 in Complex with the N-terminal region of the Nrf2 transcription factor
3zgc	crystal structure of the KEAP1-NEH2 complex
3zgd	crystal structure of a KEAP1 mutant
4asc	Crystal structure of the Kelch domain of human KBTBD5
4ch9	Crystal structure of the human KLHL3 Kelch domain in complex with a WNK4 peptide
4chb	Crystal structure of the human KLHL2 Kelch domain in complex with a WNK4 peptide
4ifj	4IFJ
4ifl	Crystal Structures of apo Keap1, Keap1-peptide, and Keap1-compound complexes
4ifn	Crystal Structures of apo Keap1, Keap1-peptide, and Keap1-compound complexes
4in4	Crystal structure of cpd 15 bound to Keap1 Kelch domain
4iqk	Crystal structure of cpd 16 bound to Keap1 Kelch domain
4l7b	Structure of keap1 kelch domain with (1S,2R)-2-{[(1S)-1-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}cyclohexanecarboxylic acid
4l7c	Structure of keap1 kelch domain with 2-{[(1S)-2-{[(1R,2S)-2-(1H-tetrazol-5-yl)cyclohexyl]carbonyl}-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-1H-isoindole-1,3(2H)-dione
4l7d	Structure of keap1 kelch domain with (1S,2R)-2-{[(1S)-5-methyl-1-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}cyclohexanecarboxylic acid
4n1b	STRUCTURE OF KEAP1 KELCH DOMAIN WITH(1S,2R)-2-[(1S)-1-[(1-oxo-2,3-dihydro-1H-isoindol-2-Yl)methyl]-1,2,3,4-tetrahydroisoquinoline-2-Carbonyl]cyclohexane-1-carboxylic acid
4xmb	4XMB
4yy8	4YY8
4zgc	4ZGC
4zy3	4ZY3
5c86	5C86
5c92	5C92
5cgj	5CGJ
5fnq	5FNQ
5fnr	5FNR
5fns	5FNS
5fnt	5FNT
5fnu	5FNU
5fzj	5FZJ
5fzn	5FZN
5gq0	5GQ0

Links (links to other resources describing this domain)

• INTERPRO: IPR006652
• PFAM: Kelch motif