The domain within your query sequence starts at position 1680 and ends at position 1799; the E-value for the LH2 domain shown below is 6.76e-6.
TSYTVSVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFSDML SLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFRFQCDCWLSKSEGDRQTLRDFAC
LH2Lipoxygenase homology 2 (beta barrel) domain |
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SMART accession number: | SM00308 |
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Description: | - |
Interpro abstract (IPR001024): | This entry represents a domain found in a variety of membrane or lipid associated proteins. It is known as the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain, is found in a variety of membrane or lipid associated proteins. Structurally, this domain forms a beta-sandwich composed of two sheets of four strands each [ (PUBMED:10469604) (PUBMED:11985859) (PUBMED:11412104) ]. The most highly conserved regions coincide with the beta-strands, with most of the highly conserved residues being buried within the protein. An exception to this is a surface lysine or arginine that occurs on the surface of the fifth beta-strand of the eukaryotic domains. In pancreatic lipase, the lysine in this position forms a salt bridge with the procolipase protein. The conservation of a charged surface residue may indicate the location of a conserved ligand-binding site. It is thought that this domain may mediate membrane attachment via other protein binding partners. |
GO function: | protein binding (GO:0005515) |
Family alignment: |
There are 13940 LH2 domains in 7296 proteins in SMART's nrdb database.
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