SMART: Lactamase_B domain annotation

The domain within your query sequence starts at position 30 and ends at position 199; the E-value for the Lactamase_B domain shown below is 6.69e-30.

GTNTYLVGTGSRRILIDTGEPSVPEYISCLKQALVEFDTAIQEILVTHWHSDHSGGIVDI
CKNINNDTTYCIKKLRRNPQREEIIGNGEQQFIYIENGDVVKTEGATLRVLYTPGHTDDH
MALLLEEENAIFSGDCILGEGTTIFEDLYDYMNSLNNLLKIKANIIYPGH

Lactamase_B Metallo-beta-lactamase superfamily

SMART accession number:	SM00849
Description:	Apart from the beta-lactamases a number of other proteins contain this domain (PUBMED:7588620). These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake. Except for the competence protein these proteins bind two zinc ions per molecule as cofactor.
Interpro abstract (IPR001279):	Apart from the beta-lactamases and metallo-beta-lactamases, a number of other proteins contain this domain [ (PUBMED:7588620) ]. These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake. Except for the competence protein these proteins bind two zinc ions per molecule as cofactor.
Family alignment:	View or

There are 264030 Lactamase_B domains in 263820 proteins in SMART's nrdb database.

Click on the following links for more information.

Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing Lactamase_B domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with Lactamase_B domain is also avaliable.

Click on the protein counts, or double click on taxonomic names to display all proteins containing Lactamase_B domain in the selected taxonomic class.
Cellular role (predicted cellular role)
Cellular role: metabolism
Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Neuwald AF, Liu JS, Lipman DJ, Lawrence CE
- Extracting protein alignment models from the sequence database.
- Nucleic Acids Res. 1997; 25: 1665-77
- Display abstract
- Biologists often gain structural and functional insights into a proteinsequence by constructing a multiple alignment model of the family. Here aprogram called Probe fully automates this process of model constructionstarting from a single sequence. Central to this program is a powerful newmethod to locate and align only those, often subtly, conserved patternsessential to the family as a whole. When applied to randomly chosenproteins, Probe found on average about four times as many relationships asa pairwise search and yielded many new discoveries. These include: anobscure subfamily of globins in the roundworm Caenorhabditis elegans ; twonew superfamilies of metallohydrolases; a lipoyl/biotin swinging armdomain in bacterial membrane fusion proteins; and a DH domain in the yeastBud3 and Fus2 proteins. By identifying distant relationships and mergingfamilies into superfamilies in this way, this analysis further confirmsthe notion that proteins evolved from relatively few ancient sequences.Moreover, this method automatically generates models of these ancientconserved regions for rapid and sensitive screening of sequences.
- Carfi A et al.
- The 3-D structure of a zinc metallo-beta-lactamase from Bacillus cereusreveals a new type of protein fold.
- EMBO J. 1995; 14: 4914-21
- Display abstract
- The 3-D structure of Bacillus cereus (569/H/9) beta-lactamase (EC3.5.2.6), which catalyses the hydrolysis of nearly all beta-lactams, hasbeen solved at 2.5 A resolution by the multiple isomorphous replacementmethod, with density modification and phase combination, from crystals ofthe native protein and of a specially designed mutant (T97C). The currentmodel includes 212 of the 227 amino acid residues, the zinc ion and 10water molecules. The protein is folded into a beta beta sandwich withhelices on each external face. To our knowledge, this fold has never beenobserved. An approximate internal molecular symmetry is found, with a2-fold axis passing roughly through the zinc ion and suggesting a possiblegene duplication. The active site is located at one edge of the beta betasandwich and near the N-terminal end of a helix. The zinc ion iscoordinated by three histidine residues (86, 88 and 149) and a watermolecule. A sequence comparison of the relevant metallo-beta-lactamases,based on this protein structure, highlights a few well-conserved aminoacid residues. The structure shows that most of these residues are in theactive site. Among these, aspartic acid 90 and histidine 210 participatein a proposed catalytic mechanism for beta-lactam hydrolysis.
Metabolism (metabolic pathways involving proteins which contain this domain)

Structure (3D structures containing this domain)

3D Structures of Lactamase_B domains in PDB

PDB code	Main view	Title
1a7t		METALLO-BETA-LACTAMASE WITH MES
1a8t		METALLO-BETA-LACTAMASE IN COMPLEX WITH L-159,061
1bc2		ZN-DEPENDENT METALLO-BETA-LACTAMASE FROM BACILLUS CEREUS
1bmc		STRUCTURE OF A ZINC METALLO-BETA-LACTAMASE FROM BACILLUS CEREUS
1bvt		METALLO-BETA-LACTAMASE FROM BACILLUS CEREUS 569/H/9
1dd6		IMP-1 METALLO BETA-LACTAMASE FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH A MERCAPTOCARBOXYLATE INHIBITOR
1ddk		CRYSTAL STRUCTURE OF IMP-1 METALLO BETA-LACTAMASE FROM PSEUDOMONAS AERUGINOSA
1dxk		Metallo-beta-lactamase from Bacillus cereus 569/H/9 C168S mutant
1e5d		RUBREDOXIN OXYGEN:OXIDOREDUCTASE (ROO) FROM ANAEROBE DESULFOVIBRIO GIGAS
1hlk		METALLO-BETA-LACTAMASE FROM BACTEROIDES FRAGILIS IN COMPLEX WITH A TRICYCLIC INHIBITOR
1jje		IMP-1 METALLO BETA-LACTAMASE FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH A BIARYL SUCCINIC ACID INHIBITOR (11)
1jjt		IMP-1 METALLO BETA-LACTAMASE FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH A BIARYL SUCCINIC ACID INHIBITOR (1)
1jt1		FEZ-1 metallo-beta-lactamase from Legionella gormanii modelled with D-captopril
1k07		Native FEZ-1 metallo-beta-lactamase from Legionella gormanii
1ko2		VIM-2, a Zn-beta-lactamase from Pseudomonas aeruginosa with an oxidized Cys (cysteinesulfonic)
1ko3		VIM-2, a Zn-beta-lactamase from Pseudomonas aeruginosa with Cys221 reduced
1kr3		Crystal Structure of the Metallo beta-Lactamase from Bacteroides fragilis (CfiA) in Complex with the Tricyclic Inhibitor SB-236050.
1l9y		FEZ-1-Y228A, A Mutant of the Metallo-beta-lactamase from Legionella gormanii
1m2x		Crystal Structure of the metallo-beta-lactamase BlaB of Chryseobacterium meningosepticum in complex with the inhibitor D-captopril
1mqo		Metallo-beta-lactamase BcII Cd substituted from Bacillus cereus at 1.35 angstroms resolution
1p9e		Crystal Structure Analysis of Methyl Parathion Hydrolase from Pseudomonas sp WBC-3
1qh3		HUMAN GLYOXALASE II WITH CACODYLATE AND ACETATE IONS PRESENT IN THE ACTIVE SITE
1qh5		HUMAN GLYOXALASE II WITH S-(N-HYDROXY-N-BROMOPHENYLCARBAMOYL)GLUTATHIONE
1sml		METALLO BETA LACTAMASE L1 FROM STENOTROPHOMONAS MALTOPHILIA
1vgn		Structure-based design of the irreversible inhibitors to metallo--lactamase (IMP-1)
1vme		Crystal structure of Flavoprotein (TM0755) from Thermotoga maritima at 1.80 A resolution
1wra		Crystal Structure of Phosphorylcholine Esterase Domain of the Virulence Factor Choline Binding Protein E from Streptococcus Pneumoniae
1wuo		Crystal structure of metallo-beta-lactamase IMP-1 mutant (D81A)
1wup		Crystal structure of metallo-beta-lactamase IMP-1 mutant (D81E)
1ww1		Crystal structure of tRNase Z from Thermotoga maritima
1x8g		Crystal Structure of the Mono-Zinc Carbapenemase CphA from Aeromonas Hydrophyla
1x8h		The Mono-Zinc Carbapenemase CphA (N220G mutant) Shows a Zn(II)- NH2 ARG Coordination
1x8i		Crystal Structure of the Zinc Carbapenemase CphA in Complex with the Antibiotic Biapenem
1xm8		X-RAY STRUCTURE OF GLYOXALASE II FROM ARABIDOPSIS THALIANA GENE AT2G31350
1y44		Crystal structure of RNase Z
1ycf		Oxidized (di-ferric) FprA from Moorella thermoacetica
1ycg		X-ray Structures of Moorella thermoacetica FprA. Novel Diiron Site Structure and Mechanistic Insights into a Scavenging Nitric Oxide Reductase
1ych		X-ray Crystal Structures of Moorella thermoacetica FprA. Novel Diiron Site Structure and Mechanistic Insights into a Scavenging Nitric Oxide Reductase
1zkp		1.5A Resolution Crystal Structure of a Metallo Beta Lactamase Family Protein, the ELAC Homolgue of Bacillus anthracis, a Putative Ribonuclease
1znb		METALLO-BETA-LACTAMASE
1ztc		Crystal structure of a putative metallo-beta-lactamase (tm0894) from Thermotoga maritima at 2.10 A resolution
2a7m		1.6 Angstrom Resolution Structure of the Quorum-Quenching N-Acyl Homoserine Lactone Hydrolase of Bacillus thuringiensis
2aio		Metallo beta lactamase L1 from Stenotrophomonas maltophilia complexed with hydrolyzed moxalactam
2az4		Crystal Structure of a Protein of Unknown Function from Enterococcus faecalis V583
2bc2		METALLO BETA-LACTAMASE II FROM BACILLUS CEREUS 569/H/9 AT PH 6.0, TRIGONAL CRYSTAL FORM
2bfk		Bacillus cereus metallo-beta-lactamase (BcII) Arg (121) Cys mutant. Solved at pH7 using 20mM ZnSO4 in buffer. 1mM DTT was used as a reducing agent
2bfl		Bacillus cereus metallo-beta-lactamase (BcII) Arg (121) Cys mutant. Solved at pH5 using 20mM ZnSO4 in buffer. 1mM DTT was used as a reducing agent.
2bfz		Bacillus cereus metallo-beta-lactamase (BcII) Arg (121) Cys mutant. Solved at pH4.5 using 20mM ZnSO4 in buffer. 1mM DTT was used as a reducing agent. Cys221 is oxidized.
2bg2		Bacillus cereus metallo-beta-lactamase (BcII) Arg (121) Cys mutant. Solved at pH4.5 using 20mM ZnSO4 in the buffer. 1mM DTT and 1mM TCEP- HCl were used as reducing agents. Cys221 is reduced.
2bg6		Bacillus cereus metallo-beta-lactamase (BcII) Arg (121) Cys mutant. Solved at pH5 using 20 Micromolar ZnSO4 in the buffer. 1mM DTT was used as a reducing agent. Cys221 is oxidized.
2bg7		Bacillus cereus metallo-beta-lactamase (BcII) Arg (121) Cys mutant. Solved at pH4.5 using 20 Micromolar ZnSO4 in the buffer. 1mM DTT was used as a reducing agent. Cys221 is oxidized.
2bg8		Bacillus cereus metallo-beta-lactamase (BcII) Arg (121) Cys mutant. Solved at pH4.5 using 20 Micromolar ZnSO4 in the buffer. 1mM DTT and 1mM TCEP-HCl were used as reducing agents.
2bga		Bacillus cereus metallo-beta-lactamase (BcII) Arg (121) Cys mutant. Solved at pH7 using 20 Micromolar ZnSO4 in the buffer. 1mM DTT was used as a reducing agent. Cys221 is oxidized.
2bib		Crystal structure of the complete modular teichioic acid phosphorylcholine esterase Pce (CbpE) from Streptococcus pneumoniae
2bmi		METALLO-BETA-LACTAMASE
2br6		Crystal Structure of Quorum-Quenching N-Acyl Homoserine Lactone Lactonase
2btn		Crystal Structure and Catalytic Mechanism of the Quorum-Quenching N- Acyl Homoserine Lactone Hydrolase
2cbn		Crystal structure of ZipD from Escherichia coli
2cfu		Crystal structure of SdsA1, an alkylsulfatase from Pseudomonas aeruginosa, in complex with 1-decane-sulfonic-acid.
2cfz		Crystal structure of SdsA1, an alkylsulfatase from Pseudomonas aeruginosa, in complex with 1-dodecanol.
2cg2		Crystal structure of SdsA1, an alkylsulfatase from Pseudomonas aeruginosa, in complex with sulfate
2cg3		Crystal structure of SdsA1, an alkylsulfatase from Pseudomonas aeruginosa.
2dkf		Crystal Structure of TTHA0252 from Thermus thermophilus HB8, a RNA Degradation Protein of the Metallo-beta-lactamase Superfamily
2doo		The structure of IMP-1 complexed with the detecting reagent (DansylC4SH) by a fluorescent probe
2e7y		High resolution structure of T. maritima tRNase Z
2fhx		Pseudomonas aeruginosa SPM-1 metallo-beta-lactamase
2fk6		Crystal Structure of RNAse Z/tRNA(Thr) complex
2fm6		Zinc-beta-lactamase L1 from stenotrophomonas maltophilia (native form)
2fu6		Zinc-beta-lactamase l1 from stenotrophomonas maltophilia (apo form)
2fu7		Zinc-beta-lactamase L1 from stenotrophomonas maltophilia (Cu-substituted form)
2fu8		Zinc-beta-lactamase L1 from stenotrophomonas maltophilia (d-captopril complex)
2fu9		Zinc-beta-lactamase L1 from stenotrophomonas maltophilia (mp2 inhibitor complex)
2gcu		X-Ray Structure of Gene Product from Arabidopsis Thaliana At1g53580
2gfj		Crystal structure of the zinc-beta-lactamase L1 from stenotrophomonas maltophilia (inhibitor 1)
2gfk		Crystal structure of the zinc-beta-lactamase l1 from stenotrophomonas maltophilia (inhibitor 2)
2gkl		Crystal structure of the zinc carbapenemase CPHA in complex with the inhibitor pyridine-2,4-dicarboxylate
2gmn		Crystal structure of BJP-1, a subclass B3 metallo-beta-lactamase of Bradyrhizobium japonicum
2h6a		Crystal structure of the zinc-beta-lactamase L1 from Stenotrophomonas maltophilia (mono zinc form)
2hb9		Crystal Structure of the Zinc-Beta-Lactamase L1 from Stenotrophomonas Maltophilia (Inhibitor 3)
2i7t		Structure of human CPSF-73
2i7v		Structure of Human CPSF-73
2m5c		Solution Structure of the Bacillus cereus Metallo-Beta-Lactamase BcII
2m5d		Solution Structure of the Bacillus cereus Metallo-Beta-Lactamase BcII in Complex with R-Thiomandelic Acid
2nxa		Structure of Zn-dependent Metallo-Beta-Lactamase from Bacillus Cereus R121H, C221D Double Mutant
2nyp		Structure of beta-lactamase II from Bacillus cereus. R121H, C221D doble mutant with two zinc ions.
2nze		Structure of beta-lactamase II from Bacillus cereus. R121H, C221S double mutant. Space group P3121.
2nzf		Structure of beta-lactamase II from Bacillus cereus. R121H, C221S double mutant. Space group C2.
2ohh		Crystal Structure of coenzyme F420H2 oxidase (FprA), a diiron flavoprotein, active oxidized state
2ohi		Crystal Structure of coenzyme F420H2 oxidase (FprA), a diiron flavoprotein, reduced state
2ohj		Crystal Structure of coenzyme F420H2 oxidase (FprA), a diiron flavoprotein, inactive oxidized state
2p18		Crystal structure of the Leishmania infantum glyoxalase II
2p1e		Crystal structure of the Leishmania infantum glyoxalase II with D-Lactate at the active site
2p4z		A Ferredoxin-like Metallo-beta-lactamase Superfamily Protein from Thermoanaerobacter tengcongensis
2p97		CRYSTAL STRUCTURE OF A PUTATIVE METAL-DEPENDENT HYDROLASE (AVA_3068) FROM ANABAENA VARIABILIS ATCC 29413 AT 1.65 A RESOLUTION
2q0i		Structure of Pseudomonas Quinolone Signal Response Protein PqsE
2q0j		Structure of Pseudomonas Quinolone Signal Response Protein PqsE
2q42		Ensemble refinement of the protein crystal structure of glyoxalase II from Arabidopsis thaliana gene At2g31350
2q9u		Crystal structure of the flavodiiron protein from Giardia intestinalis
2qds		Crystal Structure of the Zinc Carbapenemase CPHA in Complex with the Inhibitor D-Captopril
2qdt		Structural Basis for the Broad-Spectrum Inhibition of Metallo-{Beta}-Lactamases: L1- IS38 Complex
2qed		Crystal structure of Salmonella thyphimurium LT2 glyoxalase II
2qin		Stenotrophomonas maltophilia L1 Metallo-beta-Lactamase Asp-120 Cys mutant
2qjs		Stenotrophomonas maltophilia L1 metallo-beta-lactamase Asp-120 Asn mutant
2r2d		Structure of a quorum-quenching lactonase (AiiB) from Agrobacterium tumefaciens
2uyx		metallo-beta-lactamase (1BC2) single point mutant D120S
2vw8		Crystal Structure of Quinolone signal response protein pqsE from Pseudomonas aeruginosa
2whg		Crystal Structure of the Di-Zinc Metallo-beta-lactamase VIM-4 from Pseudomonas aeruginosa
2wrs		Crystal Structure of the Mono-Zinc Metallo-beta-lactamase VIM-4 from Pseudomonas aeruginosa
2wyl		Apo structure of a metallo-b-lactamase
2wym		Structure of a metallo-b-lactamase
2xf4		Crystal structure of Salmonella enterica serovar typhimurium YcbL
2xr1		DIMERIC ARCHAEAL CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR WITH N-TERMINAL KH DOMAINS (KH-CPSF) FROM METHANOSARCINA MAZEI
2y87		Native VIM-7. Structural and computational investigations of VIM-7: Insights into the substrate specificity of VIM metallo-beta- lactamases
2y8a		VIM-7 with Oxidised. Structural and computational investigations of VIM-7: Insights into the substrate specificity of VIM metallo-beta- lactamases
2y8b		VIM-7 with Oxidised. Structural and computational investigations of VIM-7: Insights into the substrate specificity of VIM metallo-beta- lactamases
2ycb		Structure of the archaeal beta-CASP protein with N-terminal KH domains from Methanothermobacter thermautotrophicus
2yhe		Structure determination of the stereoselective inverting sec- alkylsulfatase Pisa1 from Pseudomonas sp.
2ynt		GIM-1-3Mol native. Crystal structures of Pseudomonas aeruginosa GIM- 1: active site plasticity in metallo-beta-lactamases
2ynu		Apo GIM-1 with 2Mol. Crystal structures of Pseudomonas aeruginosa GIM-1: active site plasticity in metallo-beta-lactamases
2ynv		Cys221 oxidized, Mono zinc GIM-1 - GIM-1-Ox. Crystal structures of Pseudomonas aeruginosa GIM-1: active site plasticity in metallo-beta- lactamases
2ynw		GIM-1-2Mol native. Crystal structures of Pseudomonas aeruginosa GIM- 1: active site plasticity in metallo-beta-lactamases
2yz3		Crystallographic Investigation of Inhibition Mode of the VIM-2 Metallo-beta-lactamase from Pseudomonas aeruginosa with Mercaptocarboxylate Inhibitor
2znb		METALLO-BETA-LACTAMASE (CADMIUM-BOUND FORM)
2zo4		Crystal structure of metallo-beta-lactamase family protein TTHA1429 from Thermus thermophilus HB8
2zwr		Crystal structure of TTHA1623 from thermus thermophilus HB8
2zzi		Crystal structure of TTHA1623 in a di-iron-bound form
3a4y		Crystal Structure of H61A mutant TTHA0252 from Thermus thermophilus HB8
3adr		The first crystal structure of an archaeal metallo-beta-lactamase superfamily protein; ST1585 from Sulfolobus tokodaii
3af5		The crystal structure of an archaeal CPSF subunit, PH1404 from Pyrococcus horikoshii
3af6		The crystal structure of an archaeal CPSF subunit, PH1404 from Pyrococcus horikoshii complexed with RNA-analog
3aj3		Crystal structure of selenomethionine substituted 4-pyridoxolactonase from Mesorhizobium loti
3bc2		METALLO BETA-LACTAMASE II FROM BACILLUS CEREUS 569/H/9 AT PH 6.0, MONOCLINIC CRYSTAL FORM
3bk1		Crystal Structure Analysis of RNase J
3bk2		Crystal Structure Analysis of the RNase J/UMP complex
3bv6		Crystal structure of uncharacterized metallo protein from Vibrio cholerae with beta-lactamase like fold
3dh8		Structure of Pseudomonas Quinolone Signal Response Protein PqsE
3dha		An Ultral High Resolution Structure of N-Acyl Homoserine Lactone Hydrolase with the Product N-Hexanoyl-L-Homoserine Bound at An Alternative Site
3dhb		1.4 Angstrom Structure of N-Acyl Homoserine Lactone Hydrolase with the Product N-Hexanoyl-L-Homoserine Bound at The Catalytic Metal Center
3dhc		1.3 Angstrom Structure of N-Acyl Homoserine Lactone Hydrolase with the Product N-Hexanoyl-L-Homocysteine Bound to The catalytic Metal Center
3esh		Crystal structure of a probable metal-dependent hydrolase from Staphylococcus aureus. Northeast Structural Genomics target ZR314
3f9o		Crystal Structure of the Di-Zinc Carbapenemase CphA from Aeromonas Hydrophila
3fai		The Di Zinc Carbapenemase CphA N220G mutant
3fcz		Adaptive protein evolution grants organismal fitness by improving catalysis and flexibility
3g1p		Crystals structure of PhnP from E.coli K-12
3h3e		Crystal structure of Tm1679, A METAL-DEPENDENT HYDROLASE OF THE BETA-LACTAMASE SUPERFAMILY
3i0v		Bacillus cereus metallo-beta-lactamase: apo form
3i11		Cobalt-substituted metallo-beta-lactamase from Bacillus cereus
3i13		Bacillus cereus Zn-dependent metallo-beta-lactamase at pH 5.8
3i14		Cobalt-substituted metallo-beta-lactamase from Bacillus cereus: residue Cys168 partially oxidized
3i15		Cobalt-substituted metallo-beta-lactamase from Bacillus cereus: residue Cys168 fully oxidized
3idz		Crystal Structure of S378Q mutant TTHA0252 from Thermus thermophilus HB8
3ie0		Crystal Structure of S378Y mutant TTHA0252 from Thermus thermophilus HB8
3ie1		Crystal structure of H380A mutant TTHA0252 from Thermus thermophilus HB8 complexed with RNA
3ie2		Crystal Structure of H400V mutant TTHA0252 from Thermus thermophilus HB8
3iek		Crystal Structure of native TTHA0252 from Thermus thermophilus HB8
3iel		Crystal Structure of TTHA0252 from Thermus thermophilus HB8 complexed with UMP
3iem		Crystal Structure of TTHA0252 from Thermus thermophilus HB8 complexed with RNA analog
3iof		Crystal structure of CphA N220G mutant with inhibitor 10a
3iog		Crystal structure of CphA N220G mutant with inhibitor 18
3knr		Bacillus cereus metallo-beta-lactamase Cys221Asp mutant, 1 mM Zn(II)
3kns		Bacillus cereus metallo-beta-lactamase Cys221Asp mutant, 20 mM Zn(II)
3l6n		Crystal structure of metallo-beta-lactamase IND-7
3lvz		New refinement of the crystal structure of BJP-1, a subclass B3 metallo-beta-lactamase of Bradyrhizobium japonicum
3m8t		Crystal Structure of the complex between class B3 beta-lactamase BJP-1 and 4-nitrobenzene-sulfonamide
3md7		Crystal structure of a beta-lactamase-like protein bound to GMP from brucella melitensis
3p2u		Crystal structure of PhnP in complex with orthovanadate
3pg4		The crystal structure of New Delhi Metallo-beta lactamase (NDM-1)
3py5		Crystal structure of a beta-lactamase-like protein from brucella melitensis bound to AMP
3py6		Crystal Structure of a Beta-Lactamase-Like Protein from Brucella Melitensis bound to GMP
3q6v		Crystal Structure of Serratia fonticola Sfh-I: glycerol complex
3q6x		Crystal structure of NDM-1 in complex with hydrolyzed ampicillin
3qh8		Crystal structure of a beta-lactamase-like protein bound to AMP from brucella melitensis, long wavelength synchrotron data
3r2u		2.1 Angstrom Resolution Crystal Structure of Metallo-beta-lactamase from Staphylococcus aureus subsp. aureus COL
3rkj		Crystal Structure of New Delhi Metallo-Beta-Lactamase-1 from Klebsiella pnueumoniae
3rkk		Crystal Structure of New Delhi Metallo-Beta-Lactamase-1 from Klebsiella pneumoniae
3rpc		The crystal structure of a possible metal-dependent hydrolase from Veillonella parvula DSM 2008
3s0z		Crystal structure of New Delhi Metallo-beta-lactamase (NDM-1)
3sbl		Crystal Structure of New Delhi Metal-beta-lactamase-1 from Klebsiella pneumoniae
3sd9		Crystal structure of serratia fonticola SFH-I: Source of the nucleophile in the catalytic mechanism of mono-zinc metallo-beta-lactamases
3sfp		Crystal Structure of the Mono-Zinc-boundform of New Delhi Metallo-beta-Lactamase-1 from Klebsiella pneumoniae
3spu		apo NDM-1 Crystal Structure
3srx		New Delhi Metallo-beta-Lactamase-1 Complexed with Cd
3sw3		EDTA-free crystal structure of the mutant C221D of carbapenemase CphA from Aeromonas hydrophila
3t3n		Molecular basis for the recognition and cleavage of RNA (UUCCGU) by the bifunctional 5'-3' exo/endoribonuclease RNase J
3t3o		Molecular basis for the recognition and cleavage of RNA (CUGG) by the bifunctional 5'-3' exo/endoribonuclease RNase J
3t9m		Crystal structure of Mutant C221D of Carbapenemase CphA from Aeromonas Hydrophila
3tp9		Crystal structure of Alicyclobacillus acidocaldarius protein with beta-lactamase and rhodanese domains
3vpe		Crystal Structure of Metallo-beta-Lactamase SMB-1
3vqz		Crystal structure of metallo-beta-lactamase, SMB-1, in a complex with mercaptoacetic acid
3wxc		3WXC
3x2x		3X2X
3x2y		3X2Y
3x2z		3X2Z
3x30		3X30
3znb		METALLO-BETA-LACTAMASE (ZN, HG-BOUND FORM)
3zq4		Unusual, dual endo- and exo-nuclease activity in the degradosome explained by crystal structure analysis of RNase J1
3zr9		Structure of New Delhi Metallo-Beta-lactamase 1 (NDM-1)
3zwf		Crystal structure of Human tRNase Z, short form (ELAC1).
4ad9		Crystal structure of human LACTB2.
4av7		Structure determination of the double mutant S233Y F250G from the sec- alkyl sulfatase PisA1
4awy		Crystal Structure of the Mobile Metallo-beta-Lactamase AIM-1 from Pseudomonas aeruginosa: Insights into Antibiotic Binding and the role of Gln157
4awz		Crystal Structure of the Mobile Metallo-beta-Lactamase AIM-1 from Pseudomonas aeruginosa: Insights into Antibiotic Binding and the role of Gln157
4ax0		Q157A mutant. Crystal Structure of the Mobile Metallo-beta-Lactamase AIM-1 from Pseudomonas aeruginosa: Insights into Antibiotic Binding and the role of Gln157
4ax1		Q157N mutant. Crystal Structure of the Mobile Metallo-beta-Lactamase AIM-1 from Pseudomonas aeruginosa: Insights into Antibiotic Binding and the role of Gln157
4axh		Structure and mechanism of the first inverting alkylsulfatase specific for secondary alkylsulfatases
4b87		Crystal structure of human DNA cross-link repair 1A
4bp0		4BP0
4bz3		4BZ3
4c09		4C09
4c1c		4C1C
4c1d		4C1D
4c1e		4C1E
4c1f		4C1F
4c1g		4C1G
4c1h		4C1H
4chl		4CHL
4d02		4D02
4d1t		4D1T
4d1u		4D1U
4d1v		4D1V
4d1w		4D1W
4dik		Flavo Di-iron protein H90A mutant from Thermotoga maritima
4dil		Flavo Di-iron protein H90N mutant from Thermotoga maritima
4efz		Crystal Structure of a hypothetical metallo-beta-lactamase from Burkholderia pseudomallei
4exs		Crystal structure of NDM-1 bound to L-captopril
4exy		Crystal structure of NDM-1 bound to ethylene glycol
4ey2		Crystal structure of NDM-1 bound to hydrolyzed methicillin
4eyb		Crystal structure of NDM-1 bound to hydrolyzed oxacillin
4eyf		Crystal structure of NDM-1 bound to hydrolyzed benzylpenicillin
4eyl		Crystal structure of NDM-1 bound to hydrolyzed meropenem
4f6h		Mutagenesis of zinc ligand residue Cys221 reveals plasticity in the IMP-1 metallo-b-lactamase active site
4f6z		Mutagenesis of zinc ligand residue Cys221 reveals plasticity in the IMP-1 metallo-b-lactamase active site
4fek		Crystal Structure of putative diflavin flavoprotein A 5 (fragment 1-254) from Nostoc sp. PCC 7120, Northeast Structural Genomics Consortium Target NsR435A , Northeast Structural Genomics Consortium (NESG) Target NsR435A
4fr7		Crystal structure of the metallo-beta-lactamase VIM-31 in its reduced form at 1.61 A
4fsb		Crystal structure of the metallo-beta-lactamase VIM-31 in its oxidized form at 1.88 A
4gcw		Crystal structure of RNase Z in complex with precursor tRNA(Thr)
4gyq		Crystal Structure of New Delhi Metallo-beta-Lactamase-1 D223A mutant from Klebsiella pneumoniae
4gyu		Crystal Structure of New Delhi Metallo-beta-Lactamase-1 A121F mutant from Klebsiella pneumoniae
4h0d		New Delhi Metallo-beta-Lactamase-1 Complexed with Mn from Klebsiella pneumoniae
4hky		New Delhi Metallo-beta-Lactamase-1, Complexed with Cd and Faropenem
4hl1		Crystal Structure of New Delhi Metallo-beta-Lactamase-1, Complexed with Cd and Ampicillin
4hl2		New Delhi Metallo-beta-Lactamase-1 1.05 A structure Complexed with Hydrolyzed Ampicillin
4j5f		Crystal Structure of B. thuringiensis AiiA mutant F107W
4j5h		Crystal Structure of B. thuringiensis AiiA mutant F107W with N-decanoyl-L-homoserine bound at the active site
4jo0		Crystal Structure of CmlA, a diiron beta-hydroxylase from Streptomyces venezuelae
4kep		Crystal structure of 4-pyridoxolactonase, wild-type
4keq		Crystal structure of 4-pyridoxolactonase, 5-pyridoxolactone bound
4le6		Crystal structure of the phosphotriesterase OPHC2 from Pseudomonas pseudoalcaligenes
4nq2		4NQ2
4nq4		4NQ4
4nq5		4NQ5
4nq6		4NQ6
4nq7		4NQ7
4nur		4NUR
4o98		4O98
4p62		4P62
4pdx		4PDX
4pvo		4PVO
4pvt		4PVT
4ram		4RAM
4raw		4RAW
4rbs		4RBS
4rl0		4RL0
4rl2		4RL2
4rm5		4RM5
4tyf		4TYF
4tyt		4TYT
4tz9		4TZ9
4tzb		4TZB
4tze		4TZE
4tzf		4TZF
4u4l		4U4L
4ua4		4UA4
4uam		4UAM
4ubq		4UBQ
4uwo		4UWO
4uwp		4UWP
4uwr		4UWR
4uws		4UWS
4v0h		4V0H
4wd6		4WD6
4xuk		4XUK
4xwt		4XWT
4xww		4XWW
4ysb		4YSB
4ysk		4YSK
4ysl		4YSL
4zej		4ZEJ
4znb		METALLO-BETA-LACTAMASE (C181S MUTANT)
4zo2		4ZO2
4zo3		4ZO3
5a0t		5A0T
5a0v		5A0V
5a23		5A23
5a5z		5A5Z
5a87		5A87
5acp		5ACP
5acq		5ACQ
5acr		5ACR
5acs		5ACS
5act		5ACT
5acu		5ACU
5acv		5ACV
5acw		5ACW
5acx		5ACX
5aeb		5AEB
5aho		5AHO
5ahr		5AHR
5aij		5AIJ
5ajl		5AJL
5axo		5AXO
5axr		5AXR
5aya		5AYA
5b15		5B15
5b1u		5B1U
5eh9		5EH9
5eht		5EHT
5ev6		5EV6
5ev8		5EV8
5evb		5EVB
5evd		5EVD
5evk		5EVK
5ew0		5EW0
5ewa		5EWA
5fqa		5FQA
5fqb		5FQB
5fqc		5FQC
5hio		5HIO
5hip		5HIP
5hiq		5HIQ
5his		5HIS
5i0p		5I0P
5iqk		5IQK
5k0w		5K0W
5lld		5LLD
5lmc		5LMC
5lsc		5LSC

Links (links to other resources describing this domain)
INTERPRO IPR001279
PFAM Lactamase_B

INTERPRO	IPR001279
PFAM	Lactamase_B

The domain within your query sequence starts at position 30 and ends at position 199; the E-value for the Lactamase_B domain shown below is 6.69e-30.

Lactamase_B

Taxonomic distribution of proteins containing Lactamase_B domain.

3D Structures of Lactamase_B domains in PDB