NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals (PMID:10221902, 11112321). NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.
NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals [ (PUBMED:10221902) ]. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologues in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.
Notch signaling: cell fate control and signal integration in development.
Science. 1999; 284: 770-6
Display abstract
Notch signaling defines an evolutionarily ancient cell interaction mechanism,which plays a fundamental role in metazoan development. Signals exchanged betweenneighboring cells through the Notch receptor can amplify and consolidatemolecular differences, which eventually dictate cell fates. Thus, Notch signalscontrol how cells respond to intrinsic or extrinsic developmental cues that arenecessary to unfold specific developmental programs. Notch activity affects theimplementation of differentiation, proliferation, and apoptotic programs,providing a general developmental tool to influence organ formation andmorphogenesis.
