The domain within your query sequence starts at position 21 and ends at position 143; the E-value for the PA2c domain shown below is 1.83e-50.

All catalytic sites are present in this domain. Check the literature (PubMed 99175087 ) for details.



Phospholipase A2
SMART accession number:SM00085
Description: -
Interpro abstract (IPR016090):

Proteins containing this domain include eukaryotic phospholipase A2 enzymes (PLA2; EC ), small lipolytic enzymes that releases fatty acids from the second carbon group of glycerol, usually in a metal-dependent reaction, to generate lysophospholipid (LysoPL) and a free fatty acid (FA) [ (PUBMED:11872155) ]. The resulting products are either dietary or used in synthetic pathways for leukotrienes and prostaglandins. Often, arachidonic acid is released as a free fatty acid and acts as second messenger in signaling networks [ (PUBMED:10331081) ]. These enzymes enable the of fatty acids and lysophospholipid by hydrolysing the 2-ester bond of 1,2-diacyl-3-sn-phosphoglycerides. In eukaryotes, PLA2 plays a pivotal role in the biosynthesis of prostaglandin and other mediators of inflammation. These enzymes are either secreted or cytosolic; the latter are either Ca dependent or Ca independent. Secreted PLA2s have also been found to specifically bind to a variety of soluble and membrane proteins in mammals, including receptors [ (PUBMED:11293116) ]. As a toxin, PLA2 is a potent presynaptic neurotoxin which blocks nerve terminals by binding to the nerve membrane and hydrolyzing stable membrane lipids [ (PUBMED:11212293) ]. The products of the hydrolysis (LysoPL and FA) cannot form bilayers leading to a change in membrane conformation and ultimately to a block in the release of neurotransmitters [ (PUBMED:16805767) (PUBMED:10838563) (PUBMED:16339444) ].

The phospholipase domain adopts an alpha-helical secondary structure, consisting of five alpha-helices and two helical segments. PLA2 may form dimers or oligomers [ (PUBMED:11080675) (PUBMED:11897785) (PUBMED:12161451) ].

GO process:arachidonic acid secretion (GO:0050482), phospholipid metabolic process (GO:0006644)
GO function:phospholipase A2 activity (GO:0004623)
Family alignment:
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There are 5804 PA2c domains in 5499 proteins in SMART's nrdb database.

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