The domain within your query sequence starts at position 75 and ends at position 141; the E-value for the PAS domain shown below is 1.05e-9.



PAS domain
SMART accession number:SM00091
Description: PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels ([1]; Ponting & Aravind, in press).
Interpro abstract (IPR000014):

PAS domains are involved in many signalling proteins where they are used as a signal sensor domain [ (PUBMED:10357859) ]. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. The PAS domain was named after three proteins that it occurs in:

  • Per- period circadian protein
  • Arnt- Ah receptor nuclear translocator protein
  • Sim- single-minded protein.

PAS domains are often associated with PAC domains IPR001610 . It appears that these domains are directly linked, and that together they form the conserved 3D PAS fold. The division between the PAS and PAC domains is caused by major differences in sequences in the region connecting these two motifs [ (PUBMED:15009198) ]. In human PAS kinase, this region has been shown to be very flexible, and adopts different conformations depending on the bound ligand [ (PUBMED:12377121) ]. Probably the most surprising identification of a PAS domain was that in EAG-like K -channels [ (PUBMED:9301332) ].

Family alignment:
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There are 613402 PAS domains in 396128 proteins in SMART's nrdb database.

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