PDB code | Main view | Title | 1e7u | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=1e7u&file=traces.jpg) | Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine |
1e7v | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=1e7v&file=traces.jpg) | Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine |
1e8w | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=1e8w&file=traces.jpg) | Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine |
1e8x | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=1e8x&file=traces.jpg) | STRUCTURAL INSIGHTS INTO PHOSHOINOSITIDE 3-KINASE ENZYMATIC MECHANISM AND SIGNALLING |
1e8y | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=1e8y&file=traces.jpg) | Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine |
1e8z | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=1e8z&file=traces.jpg) | Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine |
1e90 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=1e90&file=traces.jpg) | Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine |
1he8 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=1he8&file=traces.jpg) | Ras G12V - PI 3-kinase gamma complex |
2a4z | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=2a4z&file=traces.jpg) | Crystal Structure of human PI3Kgamma complexed with AS604850 |
2a5u | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=2a5u&file=traces.jpg) | Crystal Structure of human PI3Kgamma complexed with AS605240 |
2chw | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=2chw&file=traces.jpg) | A pharmacological map of the PI3-K family defines a role for p110 alpha in signaling: The structure of complex of phosphoinositide 3- kinase gamma with inhibitor PIK-39 |
2chx | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=2chx&file=traces.jpg) | A pharmacological map of the PI3-K family defines a role for p110alpha in signaling: The structure of complex of phosphoinositide 3-kinase gamma with inhibitor PIK-90 |
2chz | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=2chz&file=traces.jpg) | A pharmacological map of the PI3-K family defines a role for p110alpha in signaling: The structure of complex of phosphoinositide 3-kinase gamma with inhibitor PIK-93. |
2rd0 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=2rd0&file=traces.jpg) | Structure of a human p110alpha/p85alpha complex |
2v4l | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=2v4l&file=traces.jpg) | complex of human phosphoinositide 3-kinase catalytic subunit gamma ( p110 gamma) with PIK-284 |
2wxf | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=2wxf&file=traces.jpg) | The crystal structure of the murine class IA PI 3-kinase p110delta in complex with PIK-39. |
2wxg | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=2wxg&file=traces.jpg) | The crystal structure of the murine class IA PI 3-kinase p110delta in complex with SW13. |
2wxh | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=2wxh&file=traces.jpg) | The crystal structure of the murine class IA PI 3-kinase p110delta in complex with SW14. |
2wxi | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=2wxi&file=traces.jpg) | The crystal structure of the murine class IA PI 3-kinase p110delta in complex with SW30. |
2wxj | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=2wxj&file=traces.jpg) | The crystal structure of the murine class IA PI 3-kinase p110delta in complex with INK654. |
2wxk | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=2wxk&file=traces.jpg) | The crystal structure of the murine class IA PI 3-kinase p110delta in complex with INK666. |
2wxl | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=2wxl&file=traces.jpg) | The crystal structure of the murine class IA PI 3-kinase p110delta in complex with ZSTK474. |
2wxm | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=2wxm&file=traces.jpg) | The crystal structure of the murine class IA PI 3-kinase p110delta in complex with DL06. |
2wxn | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=2wxn&file=traces.jpg) | The crystal structure of the murine class IA PI 3-kinase p110delta in complex with DL07. |
2wxo | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=2wxo&file=traces.jpg) | The crystal structure of the murine class IA PI 3-kinase p110delta in complex with AS5. |
2wxp | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=2wxp&file=traces.jpg) | The crystal structure of the murine class IA PI 3-kinase p110delta in complex with GDC-0941. |
2wxq | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=2wxq&file=traces.jpg) | The crystal structure of the murine class IA PI 3-kinase p110delta in complex with AS15. |
2wxr | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=2wxr&file=traces.jpg) | The crystal structure of the murine class IA PI 3-kinase p110delta. |
2x38 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=2x38&file=traces.jpg) | The crystal structure of the murine class IA PI 3-kinase p110delta in complex with IC87114. |
2x6f | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=2x6f&file=traces.jpg) | THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH 3-METHYLADENINE |
2x6h | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=2x6h&file=traces.jpg) | THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 |
2x6i | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=2x6i&file=traces.jpg) | THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH PIK-90 |
2x6j | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=2x6j&file=traces.jpg) | THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH PIK-93 |
2x6k | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=2x6k&file=traces.jpg) | THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH PI-103 |
2y3a | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=2y3a&file=traces.jpg) | Crystal structure of p110beta in complex with icSH2 of p85beta and the drug GDC-0941 |
3apc | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3apc&file=traces.jpg) | Crystal structure of human PI3K-gamma in complex with CH5132799 |
3apd | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3apd&file=traces.jpg) | Crystal structure of human PI3K-gamma in complex with CH5108134 |
3apf | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3apf&file=traces.jpg) | Crystal structure of human PI3K-gamma in complex with CH5039699 |
3csf | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3csf&file=traces.jpg) | Crystal structure of PI3K p110gamma catalytical domain in complex with organoruthenium inhibitor DW2 |
3cst | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3cst&file=traces.jpg) | Crystal structure of PI3K p110gamma catalytical domain in complex with organoruthenium inhibitor E5E2 |
3dbs | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3dbs&file=traces.jpg) | Structure of PI3K gamma in complex with GDC0941 |
3dpd | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3dpd&file=traces.jpg) | Achieving multi-isoform PI3K inhibition in a series of substituted 3,4-Dihydro-2H-benzo[1,4]oxazines |
3ene | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3ene&file=traces.jpg) | Complex of PI3K gamma with an inhibitor |
3hhm | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3hhm&file=traces.jpg) | Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha and the drug wortmannin |
3hiz | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3hiz&file=traces.jpg) | Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha |
3ibe | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3ibe&file=traces.jpg) | Crystal Structure of a Pyrazolopyrimidine Inhibitor Bound to PI3 Kinase Gamma |
3ihy | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3ihy&file=traces.jpg) | Human PIK3C3 crystal structure |
3jbz | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3jbz&file=traces.jpg) | 3JBZ |
3l08 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3l08&file=traces.jpg) | Structure of Pi3K gamma with a potent inhibitor: GSK2126458 |
3l13 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3l13&file=traces.jpg) | Crystal Structures of Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors |
3l16 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3l16&file=traces.jpg) | Discovery of (thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer |
3l17 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3l17&file=traces.jpg) | Discovery of (thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer |
3l54 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3l54&file=traces.jpg) | Structure of Pi3K gamma with inhibitor |
3lj3 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3lj3&file=traces.jpg) | PI3-kinase-gamma with a pyrrolopyridine-benzofuran inhibitor |
3ls8 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3ls8&file=traces.jpg) | Crystal structure of human PIK3C3 in complex with 3-[4-(4-Morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-phenol |
3mjw | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3mjw&file=traces.jpg) | PI3 Kinase gamma with a benzofuranone inhibitor |
3ml8 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3ml8&file=traces.jpg) | Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04691502 through Structure Based Drug Design |
3ml9 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3ml9&file=traces.jpg) | Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04691502 through Structure Based Drug Design |
3nzs | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3nzs&file=traces.jpg) | Structure-based Optimization of Pyrazolo -Pyrimidine and -Pyridine Inhibitors of PI3-Kinase |
3nzu | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3nzu&file=traces.jpg) | Structure-based Optimization of Pyrazolo -Pyrimidine and -Pyridine Inhibitors of PI3-Kinase |
3oaw | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3oaw&file=traces.jpg) | 4-Methylpteridineones as Orally Active and Selective PI3K/mTOR Dual Inhibitors |
3p2b | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3p2b&file=traces.jpg) | Crystal Structure of PI3K gamma with 3-(2-morpholino-6-(pyridin-3-ylamino)pyrimidin-4-yl)phenol |
3pre | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3pre&file=traces.jpg) | Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors. |
3prz | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3prz&file=traces.jpg) | Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors. |
3ps6 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3ps6&file=traces.jpg) | Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors. |
3qaq | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3qaq&file=traces.jpg) | Crystal structure of PI3K-gamma in complex with triazine-benzimidazole 1 |
3qar | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3qar&file=traces.jpg) | Crystal structure of PI3K-gamma in complex with triazine-benzimidazole 32 |
3qjz | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3qjz&file=traces.jpg) | Crystal structure of PI3K-gamma in complex with benzothiazole 1 |
3qk0 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3qk0&file=traces.jpg) | Crystal structure of PI3K-gamma in complex with benzothiazole 82 |
3r7q | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3r7q&file=traces.jpg) | Structure-based design of thienobenzoxepin inhibitors of PI3- kinase |
3r7r | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3r7r&file=traces.jpg) | Structure-based design of thienobenzoxepin inhibitors of PI3-Kinase |
3s2a | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3s2a&file=traces.jpg) | Crystal structure of PI3K-gamma in complex with a quinoline inhibitor |
3sd5 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3sd5&file=traces.jpg) | Crystal Structure of PI3K gamma with 5-(2,4-dimorpholinopyrimidin-6-yl)-4-(trifluoromethyl)pyridin-2-amine |
3t8m | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3t8m&file=traces.jpg) | Rational Design of PI3K-alpha Inhibitors that Exhibit Selectivity Over the PI3K-beta Isoform |
3tjp | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3tjp&file=traces.jpg) | Crystal Structure of PI3K gamma with N6-(3,4-dimethoxyphenyl)-2-morpholino-[4,5'-bipyrimidine]-2',6-diamine |
3tl5 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3tl5&file=traces.jpg) | Discovery of GDC-0980: a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor for the Treatment of Cancer |
3zim | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3zim&file=traces.jpg) | Discovery of a potent and isoform-selective targeted covalent inhibitor of the lipid kinase PI3Kalpha |
3zvv | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3zvv&file=traces.jpg) | Fragment Bound to PI3KInase gamma |
3zw3 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=3zw3&file=traces.jpg) | Fragment based discovery of a novel and selective PI3 Kinase inhibitor |
4a55 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4a55&file=traces.jpg) | Crystal structure of p110alpha in complex with iSH2 of p85alpha and the inhibitor PIK-108 |
4ajw | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4ajw&file=traces.jpg) | Discovery and Optimization of New Benzimidazole- and Benzoxazole-Pyrimidone Selective PI3KBeta Inhibitors for the Treatment of Phosphatase and TENsin homologue (PTEN)-Deficient Cancers"" |
4anu | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4anu&file=traces.jpg) | Complexes of PI3Kgamma with isoform selective inhibitors. |
4anv | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4anv&file=traces.jpg) | Complexes of PI3Kgamma with isoform selective inhibitors. |
4anw | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4anw&file=traces.jpg) | Complexes of PI3Kgamma with isoform selective inhibitors. |
4anx | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4anx&file=traces.jpg) | Complexes of PI3Kgamma with isoform selective inhibitors. |
4aof | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4aof&file=traces.jpg) | Selective small molecule inhibitor discovered by chemoproteomic assay platform reveals regulation of Th17 cell differentiation by PI3Kgamma |
4bfr | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4bfr&file=traces.jpg) | Discovery and Optimization of Pyrimidone Indoline Amide PI3Kbeta Inhibitors for the Treatment of Phosphatase and TENsin homologue ( PTEN)-Deficient Cancers |
4d0l | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4d0l&file=traces.jpg) | 4D0L |
4d0m | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4d0m&file=traces.jpg) | 4D0M |
4dk5 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4dk5&file=traces.jpg) | Crystal structure of human PI3K-gamma in complex with a pyridyl-triazine inhibitor |
4ezj | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4ezj&file=traces.jpg) | Potent and Selective Inhibitors of PI3K-delta: Obtaining Isoform Selectivity from the Affinity Pocket and Tryptophan Shelf |
4ezk | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4ezk&file=traces.jpg) | Potent and Selective Inhibitors of PI3K-delta: Obtaining Isoform Selectivity from the Affinity Pocket and Tryptophan Shelf |
4ezl | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4ezl&file=traces.jpg) | Potent and Selective Inhibitors of PI3K-delta: Obtaining Isoform Selectivity from the Affinity Pocket and Tryptophan Shelf |
4f1s | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4f1s&file=traces.jpg) | Crystal structure of human PI3K-gamma in complex with a pyridyl-triazine-sulfonamide inhibitor |
4fa6 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4fa6&file=traces.jpg) | Design and Synthesis of a Novel Pyrrolidinyl Pyrido Pyrimidinone Derivative as a Potent Inhibitor of PI3Ka and mTOR |
4fad | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4fad&file=traces.jpg) | Design and Synthesis of a Novel Pyrrolidinyl Pyrido Pyrimidinone Derivative as a Potent Inhibitor of PI3Ka and mTOR |
4fhj | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4fhj&file=traces.jpg) | Crystal Structure of PI3K-gamma in Complex with Imidazopyridine 2 |
4fhk | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4fhk&file=traces.jpg) | Crystal Structure of PI3K-gamma in Complex with Imidazopyridazine 19e |
4fjy | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4fjy&file=traces.jpg) | Crystal structure of PI3K-gamma in complex with quinoline-indoline inhibitor 24f |
4fjz | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4fjz&file=traces.jpg) | Crystal structure of PI3K-gamma in complex with pyrrolo-pyridine inhibitor 63 |
4flh | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4flh&file=traces.jpg) | Crystal structure of human PI3K-gamma in complex with AMG511 |
4ful | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4ful&file=traces.jpg) | PI3 Kinase Gamma bound to a pyrmidine inhibitor |
4g11 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4g11&file=traces.jpg) | X-ray structure of PI3K-gamma bound to a 4-(morpholin-4-yl)- (6-oxo-1,6-dihydropyrimidin-2-yl)amide inhibitor |
4gb9 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4gb9&file=traces.jpg) | Potent and Highly Selective Benzimidazole Inhibitors of PI3K-delta |
4hle | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4hle&file=traces.jpg) | Compound 21 (1-alkyl-substituted 1,2,4-triazoles) |
4hvb | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4hvb&file=traces.jpg) | Catalytic unit of PI3Kg in complex with PI3K/mTOR dual inhibitor PF-04979064 |
4j6i | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4j6i&file=traces.jpg) | Discovery of thiazolobenzoxepin PI3-kinase inhibitors that spare the PI3-kinase beta isoform |
4jps | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4jps&file=traces.jpg) | Co-crystal Structures of the Lipid Kinase PI3K alpha with Pan and Isoform Selective Inhibitors |
4jsn | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4jsn&file=traces.jpg) | structure of mTORdeltaN-mLST8 complex |
4jsp | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4jsp&file=traces.jpg) | structure of mTORDeltaN-mLST8-ATPgammaS-Mg complex |
4jsv | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4jsv&file=traces.jpg) | mTOR kinase structure, mechanism and regulation. |
4jsx | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4jsx&file=traces.jpg) | structure of mTORDeltaN-mLST8-Torin2 complex |
4jt5 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4jt5&file=traces.jpg) | mTORdeltaN-mLST8-pp242 complex |
4jt6 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4jt6&file=traces.jpg) | structure of mTORDeltaN-mLST8-PI-103 complex |
4kz0 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4kz0&file=traces.jpg) | Structure of PI3K gamma with Imidazopyridine inhibitors |
4kzc | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4kzc&file=traces.jpg) | Structure of PI3K gamma with Imidazopyridine inhibitors |
4l1b | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4l1b&file=traces.jpg) | Crystal Structure of p110alpha complexed with niSH2 of p85alpha |
4l23 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4l23&file=traces.jpg) | Crystal Structure of p110alpha complexed with niSH2 of p85alpha and PI-103 |
4l2y | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4l2y&file=traces.jpg) | Crystal Structure of p110alpha complexed with niSH2 of p85alpha and compound 9d |
4ovu | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4ovu&file=traces.jpg) | 4OVU |
4ovv | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4ovv&file=traces.jpg) | 4OVV |
4oys | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4oys&file=traces.jpg) | 4OYS |
4ph4 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4ph4&file=traces.jpg) | 4PH4 |
4ps3 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4ps3&file=traces.jpg) | Structure of PI3K gamma in complex with 1-[6-(5-methoxypyridin-3-yl)-1,3-benzothiazol-2-yl]-3-[2-(1-propyl-1H-imidazol-4-yl)ethyl]urea |
4ps7 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4ps7&file=traces.jpg) | Structure of PI3K gamma in complex with N-[6-(pyridin-3-yl)-1,3-benzothiazol-2-yl]acetamide |
4ps8 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4ps8&file=traces.jpg) | Structure of PI3K gamma in complex with N-[6-(5,6-dimethoxypyridin-3-yl)-1,3-benzothiazol-2-yl]acetamide |
4tuu | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4tuu&file=traces.jpg) | 4TUU |
4tv3 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4tv3&file=traces.jpg) | 4TV3 |
4urk | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4urk&file=traces.jpg) | 4URK |
4uwf | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4uwf&file=traces.jpg) | 4UWF |
4uwg | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4uwg&file=traces.jpg) | 4UWG |
4uwh | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4uwh&file=traces.jpg) | 4UWH |
4uwk | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4uwk&file=traces.jpg) | 4UWK |
4uwl | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4uwl&file=traces.jpg) | 4UWL |
4v0i | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4v0i&file=traces.jpg) | 4V0I |
4wae | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4wae&file=traces.jpg) | 4WAE |
4waf | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4waf&file=traces.jpg) | 4WAF |
4wag | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4wag&file=traces.jpg) | 4WAG |
4wwn | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4wwn&file=traces.jpg) | 4WWN |
4wwo | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4wwo&file=traces.jpg) | 4WWO |
4wwp | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4wwp&file=traces.jpg) | 4WWP |
4xe0 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4xe0&file=traces.jpg) | 4XE0 |
4xx5 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4xx5&file=traces.jpg) | 4XX5 |
4xz4 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4xz4&file=traces.jpg) | 4XZ4 |
4ykn | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4ykn&file=traces.jpg) | 4YKN |
4zop | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=4zop&file=traces.jpg) | 4ZOP |
5ae8 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=5ae8&file=traces.jpg) | 5AE8 |
5ae9 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=5ae9&file=traces.jpg) | 5AE9 |
5anl | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=5anl&file=traces.jpg) | 5ANL |
5c46 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=5c46&file=traces.jpg) | 5C46 |
5c4g | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=5c4g&file=traces.jpg) | 5C4G |
5dfz | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=5dfz&file=traces.jpg) | 5DFZ |
5dxh | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=5dxh&file=traces.jpg) | 5DXH |
5dxt | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=5dxt&file=traces.jpg) | 5DXT |
5dxu | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=5dxu&file=traces.jpg) | 5DXU |
5eds | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=5eds&file=traces.jpg) | 5EDS |
5enn | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=5enn&file=traces.jpg) | 5ENN |
5euq | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=5euq&file=traces.jpg) | 5EUQ |
5fi4 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=5fi4&file=traces.jpg) | 5FI4 |
5flc | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=5flc&file=traces.jpg) | 5FLC |
5fvm | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=5fvm&file=traces.jpg) | 5FVM |
5g2n | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=5g2n&file=traces.jpg) | 5G2N |
5g55 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=5g55&file=traces.jpg) | 5G55 |
5is5 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=5is5&file=traces.jpg) | 5IS5 |
5itd | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=5itd&file=traces.jpg) | 5ITD |
5kc2 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=5kc2&file=traces.jpg) | 5KC2 |
5l72 | ![](http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/getimg.pl?source=pdbsum&pdb_code=5l72&file=traces.jpg) | 5L72 |