The domain within your query sequence starts at position 1208 and ends at position 1288; the E-value for the PKD domain shown below is 1.14e-17.



Repeats in polycystic kidney disease 1 (PKD1) and other proteins
SMART accession number:SM00089
Description: Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.
Interpro abstract (IPR022409):

The PKD (Polycystic Kidney Disease) domain was first identified in the Polycystic Kidney Disease protein, polycystin-1 (PDK1 gene), and contains an Ig-like fold consisting of a beta-sandwich of seven strands in two sheets with a Greek key topology, although some members have additional strands [ (PUBMED:9889186) ]. Polycystin-1 is a large cell-surface glycoprotein involved in adhesive protein-protein and protein-carbohydrate interactions; however it is not clear if the PKD domain mediates any of these interactions.

PKD domains are also found in other proteins, usually in the extracellular parts of proteins involved in interactions with other proteins. For example, domains with a PKD-type fold are found in archaeal surface layer proteins that protect the cell from extreme environments [ (PUBMED:12377130) ], and in the human VPS10 domain-containing receptor SorCS2 [ (PUBMED:11499680) ].

Family alignment:
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There are 95746 PKD domains in 42890 proteins in SMART's nrdb database.

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