The domain within your query sequence starts at position 497 and ends at position 614; the E-value for the ADAM_spacer1 domain shown below is 5.2e-33.



PFAM accession number:PF05986
Interpro abstract (IPR010294):

This domain represents the Spacer-1 domain from the ADAM-TS family of metalloproteinases [ (PUBMED:11279086) ].

A cellular disintegrin and metalloproteinase (ADAM) is a family of genes with structural homology to the snake venom metalloproteinases and disintegrins [ (PUBMED:8995297) ]. There is variation amongst members of the family, however, all have a similar domain organisation comprising a preproregion, a reprolysin-type catalytic domain, a disintegrin-like domain, a thrombospondin type-1 (TS) module, a cysteine-rich domain, a spacer domain without cysteine residues, and a COOH-terminal TS module [ (PUBMED:10464288) (PUBMED:11279086) ]. They are involved in embryogenesis and have been implicated in some cancers and inflammatory diseases [ (PUBMED:11279086) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry ADAM_spacer1