The domain within your query sequence starts at position 1281 and ends at position 1398; the E-value for the AKAP_110 domain shown below is 7.5e-13.



PFAM accession number:PF05716
Interpro abstract (IPR018292):

This family consists of several mammalian protein kinase A anchoring protein 3 (PRKA3) or A-kinase anchor protein 110kDa (AKAP 110) sequences. Agents that increase intracellular cAMP are potent stimulators of sperm motility. Anchoring inhibitor peptides, designed to disrupt the interaction of the cAMP-dependent protein kinase A (PKA) with A kinase-anchoring proteins (AKAPs), are potent inhibitors of sperm motility. PKA anchoring is a key biochemical mechanism controlling motility. AKAP110 shares compartments with both RI and RII isoforms of PKA and may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction [ (PUBMED:10319321) ].

This entry represents a sub group of the A-kinase anschor 110kDa protein.

This is a PFAM domain. For full annotation and more information, please see the PFAM entry AKAP_110