The domain within your query sequence starts at position 204 and ends at position 336; the E-value for the ASXH domain shown below is 4.2e-52.
AASDSVPAKPGQMKRTKCADIDVETPDSILVNTNLRALINKHTFSVLPGDCQQRLLLLLP EVDRQVGPDGLMKLNGSALNNEFFTSAAQGWKERLSEGEFTPEMQVRIRQEIEKEKKVEL WKEQFFENYYGQS
ASXH |
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PFAM accession number: | PF13919 |
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Interpro abstract (IPR028020): | This entry represents a conserved alpha helical domain with a characteristic LXXLL motif found in Asx and homologues [ (PUBMED:19270745) (PUBMED:19833123) ]. The LXXLL motif is detected in diverse transcription factors, coactivators and co-repressors and is implicated in mediating interactions between them [ (PUBMED:15691650) ]. The Asx homology (ASXH) domain is found in animals, fungi and plants [ (PUBMED:22186017) ] and is predicted to play a role in mediating contact between transcription factors and chromatin-associated complexes. In Drosophila Asx and Human ASXL1, the ASXH domain is predicted to mediate interactions with the Calypso and BAP1 deubiquitinases (DUBs) which further belong to the UCHL5/UCH37 clade of DUBs [ (PUBMED:22186017) ]. |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry ASXH