The domain within your query sequence starts at position 89 and ends at position 153; the E-value for the Arfaptin domain shown below is 1.1e-11.



PFAM accession number:PF06456
Interpro abstract (IPR010504):

The arfaptin homology (AH) domain is a protein domain found in a range of proteins, including arfaptins, protein kinase C-binding protein PICK1 [ (PUBMED:10623590) ] and mammalian 69kDa islet cell autoantigen (ICA69) [ (PUBMED:12682071) ]. The AH domain of arfaptin has been shown to dimerise and to bind Arf and Rho family GTPases [ (PUBMED:11346801) (PUBMED:11696355) ], including ARF1, a small GTPase involved in vesicle budding at the Golgi complex and immature secretory granules.

The AH domain consists of three alpha-helices arranged as an extended antiparallel alpha-helical bundle. Two arfaptin AH domains associate to form a highly elongated, crescent-shaped dimer [ (PUBMED:11346801) (PUBMED:11696355) ].

GO function:protein domain specific binding (GO:0019904)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Arfaptin