SMART: Pfam domain Borealin

The domain within your query sequence starts at position 148 and ends at position 286; the E-value for the Borealin domain shown below is 5.9e-27.

RSAKVKRCLPSKKRTQSIQGRGRSKRLSHDFVTPAMSRLEPSLVKPTPGMTPRFDSRVFK
TPGLRTPAAKEQVYNISINGSPLADSKEISLSVPIGGGASLRLLASDLQRIDIAQLNPEA
LGNIRKLSGRVILQHLCAS

Borealin

PFAM accession number:	PF10512
Interpro abstract (IPR018867):	The chromosomal passenger complex of Aurora B kinase, INCENP, and Survivin has essential regulatory roles at centromeres and the central spindle in mitosis. Cell division cycle-associated protein 8, also known as Borealin, is also a member of the complex. Approximately half of Aurora B in mitotic cells is complexed with INCENP, Borealin, and Survivin. Depletion of Borealin by RNA interference delays mitotic progression and results in kinetochore-spindle mis-attachments and an increase in bipolar spindles associated with ectopic asters [ (PUBMED:15249581) ].

PFAM accession number:

PF10512

Interpro abstract (IPR018867):

The chromosomal passenger complex of Aurora B kinase, INCENP, and Survivin has essential regulatory roles at centromeres and the central spindle in mitosis. Cell division cycle-associated protein 8, also known as Borealin, is also a member of the complex. Approximately half of Aurora B in mitotic cells is complexed with INCENP, Borealin, and Survivin. Depletion of Borealin by RNA interference delays mitotic progression and results in kinetochore-spindle mis-attachments and an increase in bipolar spindles associated with ectopic asters [ (PUBMED:15249581) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Borealin