SMART: Pfam domain CALCOCO1

The domain within your query sequence starts at position 13 and ends at position 598; the E-value for the CALCOCO1 domain shown below is 6.8e-241.

GGVNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRDYHTFVWSSVPES
TTDGSPTHASVQFQASYLPKPGAQLYQFRYVNRQGRVCGQSPPFQFREPRPMDELVTLEE
ADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEDQVTELRSRVQELEAALATAR
QEHSELTEQYKGLSRSHGELSEERDILSQQQGDHVARILELEDDIQTMSDKVLMKEVELD
RVRDTVKALTREQEKLLRQLKEFQADKEQSEAELQTVREENCCLNTELEEAKSRQEEQGA
QVQRLKDKLAHMKDTLGQAQQKVAELEPLKEQLRGVQELAASSQQKAALLGEELASAAGA
RDRTIAELHRSRLEVAEVNGRLAELSLHMKEEKCQWSKERTGLLQSMEAEKDKILKLSAE
ILRLEKTVQEERTQSHVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQTE
KQELLEYMRKLEARLEKVADEKWTEDAATEDEEATAGLSCPASLTDSEDESPEDMRLPSY
GLCESGNTSSSPPGPREPSSLVVINQPAPIAPQFSGPGEASSSDSE

CALCOCO1

PFAM accession number:	PF07888
Interpro abstract (IPR012852):	Calcium-binding and coiled-coil domain-containing protein 1 (Calcoco1) from Mus musculus ( Q8CGU1 ) binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1 ( Q61026 ), and thus enhances transcriptional activation by a number of nuclear receptors. Calcoco1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region [ (PUBMED:14690606) ].

PFAM accession number:

PF07888

Interpro abstract (IPR012852):

Calcium-binding and coiled-coil domain-containing protein 1 (Calcoco1) from Mus musculus ( Q8CGU1 ) binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1 ( Q61026 ), and thus enhances transcriptional activation by a number of nuclear receptors. Calcoco1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region [ (PUBMED:14690606) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry CALCOCO1