The domain within your query sequence starts at position 48 and ends at position 210; the E-value for the COQ7 domain shown below is 5.9e-69.



PFAM accession number:PF03232
Interpro abstract (IPR011566):

Coq7 (also known as Clk-1 and CAT5) is a di-iron carboxylate protein occuring in both prokaryotes and eukaryotes that is essential for ubiquinone biosynthesis [ (PUBMED:8621692) (PUBMED:9823893) ]. It has been implicated in the aging process as mutations in the Caenorhabditis elegans gene lead to increased lifespan [ (PUBMED:9020081) ]. Coq7 is a membrane-bound protein that functions as a monooxygenase to hydroxylate demethoxyubiquinone (DMQ or 2-methoxy-5-methyl-6-polyprenyl-1,4-benzoquinone) in the penultimate step of ubiquinone biosynthesis [ (PUBMED:11435415) ]. Biochemical studies indicate that NADH can serve directly as a reductant for catalytic activation of dioxygen and substrate oxidation by the enzyme, with no requirement for an additional reductase protein component [ (PUBMED:20923139) ]. This direct reaction with NADH is so far unique amongst members of the di-iron carboxylate protein family.

GO process:ubiquinone biosynthetic process (GO:0006744)
GO function:monooxygenase activity (GO:0004497)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry COQ7