SMART: Pfam domain CSTF1

The domain within your query sequence starts at position 6 and ends at position 62; the E-value for the CSTF1_dimer domain shown below is 5.4e-28.

VGLKDRQQLYKLIISQLLYDGYISIANGLINEIKPQSVCAPSEQLLHLIKLGMENDD

CSTF1_dimer

PFAM accession number:	PF16699
Interpro abstract (IPR032028):	This entry represents the dimerisation domain found at the N terminus of cleavage stimulation factor subunit 1 (CSTF1) from eukaryotes. This domain allows for homodimerisation such that the functional state of CSTF1 is a heterohexamer. The Cleavage stimulation Factor (CstF) complex is composed of three subunits and is essential for pre-mRNA 3'-end processing. CstF recognises U and G/U-rich cis-acting RNA sequence elements and helps to stabilise the Cleavage and Polyadenylation Specificity Factor (CPSF) at the polyadenylation site as required for productive RNA cleavage [ (PUBMED:21233223) ].

PFAM accession number:

PF16699

Interpro abstract (IPR032028):

This entry represents the dimerisation domain found at the N terminus of cleavage stimulation factor subunit 1 (CSTF1) from eukaryotes. This domain allows for homodimerisation such that the functional state of CSTF1 is a heterohexamer. The Cleavage stimulation Factor (CstF) complex is composed of three subunits and is essential for pre-mRNA 3'-end processing. CstF recognises U and G/U-rich cis-acting RNA sequence elements and helps to stabilise the Cleavage and Polyadenylation Specificity Factor (CPSF) at the polyadenylation site as required for productive RNA cleavage [ (PUBMED:21233223) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry CSTF1_dimer