The domain within your query sequence starts at position 856 and ends at position 884; the E-value for the CaM_bdg_C0 domain shown below is 3.3e-19.



PFAM accession number:PF10562
Interpro abstract (IPR018882):

This is a very short highly conserved domain that is C-terminal to the cytosolic transmembrane region IV of the NMDA-receptor 1. It has been shown to bind Calmodulin-Calcium with high affinity. The ionotropic N-methyl-D-aspartate receptor (NMDAR) is a major source of calcium flux into neurons in the brain and plays a critical role in learning, memory, neural development, and synaptic plasticity. Calmodulin (CaM) regulates NMDARs by binding tightly to the C0 and C1 regions of their NR1 subunit. The conserved tryptophan is considered to be the anchor residue [ (PUBMED:18073110) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry CaM_bdg_C0