The domain within your query sequence starts at position 2 and ends at position 158; the E-value for the DUF2053 domain shown below is 3.1e-69.

TLFHFGNCFALAYFPYFITYKCSGLSEYNAFWKCVQAGVTYLFVQLCKMLFLATFFPTWE
GGIYDFIGEFMKASVDVADLIGLNLVMSRNAGKGEYKIMVAALGWATAELIMSRCIPLWV
GARGIEFDWKYIQMSIDSNISLVHYIVASAQVWMITR

DUF2053

 DUF2053
PFAM accession number:PF09767
Interpro abstract (IPR019164):

TMEM147 is a component of the Nicalin-NOMO protein complex, which catalyzes the proteolytic cleavage of the transmembrane domain of various proteins including the beta-amyloid precursor protein and Notch [ (PUBMED:20538592) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry DUF2053