The domain within your query sequence starts at position 1 and ends at position 160; the E-value for the DUF3808 domain shown below is 2.6e-53.



PFAM accession number:PF10300
Interpro abstract (IPR019412):

This entry represents a family of proteins conserved from fungi to humans, including fungal Iml2 protein, animal tetratricopeptide repeat protein 39A/B/C (TT39A/B/C) and some characterised proteins. Members of this family carry a tetratricopeptide repeat ( IPR013105 ) at their C terminus.

In Saccharomyces cerevisiae, Iml2 and its paralogue-YKR018C are included in this entry. Iml2 localises to the cytoplasm and nucleus [ (PUBMED:14562095) ], and its expression is increased in response to DNA replication stress [ (PUBMED:22842922) ]. It is found to be involved in lipid droplet-mediated inclusion body clearing after protein folding stress [ (PUBMED:26004510) ].

In humans TTC39A (also known as DEME6) is expressed in primary breast carcinomas but not in normal breast tissue, and has a putative eukaryotic RNP-1 RNA binding region and a candidate anchoring transmembrane domain. It is coordinately regulated with oestrogen receptor, but is not necessarily oestradiol-responsive [ (PUBMED:9461476) ]. TTC39B has been linked to lipid metabolism [ (PUBMED:20686565) (PUBMED:21738485) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry DUF3808