SMART: Pfam domain DUF3827

The domain within your query sequence starts at position 498 and ends at position 1134; the E-value for the DUF3827 domain shown below is 2.4e-282.

WKPQPAGAFQLKTVLQFVSQSDNIQSCRFAQTMEQRLQKAFQDAERKVLSTRSNLTVQIV
STSNASQAVTLVYAVGNQSSFLNGTVASSLLSQLSAELVGFYLTYPPLTIAEPLEYPNLD
TSETTRDYWVITVLQGVDNSLVGLHNQSFARVMEQRLAQLFMMSQQQGRRFKRATTLGSY
TVQMVKMQRVPGPKDPAELTYYTLYNGKPLLGTAAAKILSTIDSQRMALTLHHVVLLQAD
PVVKNPPNNLWIIAAVLAPIAVVTIIIIIITAVLCRKNKNDFKPDTMINLPQRAKPVQGF
DYAKQHLGQQGADEEVIPVTQETVVLPIPVRDTPQERDTAQDGSAIKTAKSTETRRRSPS
ENGSVISNESGKPSSGRRSPQNGMTQQKVTKEESRKRNVTASDEEEGAGLFDSAGKAAAD
PFDTSSGSVQLIAIKPSALPVVHPASDRGQESSAALNGEVNKALKQKSDIEHYRNKLRLK
AKRKGYYDFPPVEAGKGLAERKMYEKAPKEVEHVLDADPELCAPFAESKNRQQMKNSVYR
SRQSLNSPSPGETEMDLLVTRERPRRGIRNSGYDTEPEIIEETNVDRVHEPRGYGRARQA
KGHSETSTLSSQPSIDEVRQQMHMLLEEAFSLASAGH

DUF3827

PFAM accession number:	PF12877
Interpro abstract (IPR024606):	The function of the proteins in this entry is not currently known, but one of the human proteins ( Q9HCM3 ) has been implicated in pilocytic astrocytomas [ (PUBMED:18974108) (PUBMED:19363522) (PUBMED:19937730) ]. In the majority of cases of pilocytic astrocytomas a tandem duplication produces an in-frame fusion of the gene encoding this protein and the BRAF oncogene. The resulting fusion protein has constitutive BRAF kinase activity and is capable of transforming cells.

PFAM accession number:

PF12877

Interpro abstract (IPR024606):

The function of the proteins in this entry is not currently known, but one of the human proteins ( Q9HCM3 ) has been implicated in pilocytic astrocytomas [ (PUBMED:18974108) (PUBMED:19363522) (PUBMED:19937730) ]. In the majority of cases of pilocytic astrocytomas a tandem duplication produces an in-frame fusion of the gene encoding this protein and the BRAF oncogene. The resulting fusion protein has constitutive BRAF kinase activity and is capable of transforming cells.

This is a PFAM domain. For full annotation and more information, please see the PFAM entry DUF3827