The domain within your query sequence starts at position 4 and ends at position 182; the E-value for the DUF758 domain shown below is 2.4e-75.



PFAM accession number:PF05527
Interpro abstract (IPR008477):

Four tumor necrosis factor alpha-induced protein 8-like proteins have been identified: TNFAIP8 (also known as TIPE), TIPE1, TIPE2 and TIPE3. Overexpressed TIPE in cells can reduce cell death in vitro and increase tumor growth in vivo [ (PUBMED:10644768) ]. By contrast, TIPE2 has been demonstrated to be an inhibitor of Ras and to have a pro-apoptotic ability. TIPE1 could upregulate the pro-apoptotic members of the B-cell leukemia/lymphoma (Bcl)-2 family of proteins [ (PUBMED:27900028) ].

GO process:regulation of apoptotic process (GO:0042981)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry DUF758