The domain within your query sequence starts at position 2 and ends at position 74; the E-value for the Dpoe2NT domain shown below is 1.9e-32.
APERLRSRTVSAFKLRGLLLRSEATKYLTEALQSVTELELEENLGKIIDAVEKQPLSSNM IERSVVEAAVQEC
Dpoe2NT |
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PFAM accession number: | PF12213 |
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Interpro abstract (IPR024639): | This domain is found in the N-terminal of DNA polymerase epsilon subunit B proteins. It contains a single completely conserved phenylalanine residue that may be functionally important. It forms a primarily alpha helical structure in which four helices are arranged in two hairpins with connecting loops containing beta strands which form a short parallel sheet. DNA polymerase epsilon is required in DNA replication for synthesis of the leading strand. The N-terminal domain has close structural relation to AAA+ protein C-terminal domains [ (PUBMED:18676977) ]. |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry Dpoe2NT