The domain within your query sequence starts at position 16 and ends at position 400; the E-value for the Dynamitin domain shown below is 7.1e-129.



PFAM accession number:PF04912
Interpro abstract (IPR028133):

Dynactin is a multiprotein complex necessary for the function of microtubule motor protein dynein. The dynein-dynactin complex is involved in a variety of cellular events, including membrane vesicle transport, mitotic spindle assembly and centrosome separation [ (PUBMED:19935668) (PUBMED:9522459) (PUBMED:10047518) ].

Dynamitin (dynactin subunit 2, DCTN2) is a subunit of the dynactin complex. In Saccharomyces cerevisiae it is also known as Jnm1. Dynactin contains two distinct structural domains: a projecting sidearm that interacts with dynein and an actin-like minifilament backbone that is thought to bind cargo. Dynamitin holds together both structural domains [ (PUBMED:10525537) ]. Dynamitin is implicated in cell adhesion by binding to macrophage-enriched myristoylated alanine-rice C kinase substrate (MacMARCKS) [ (PUBMED:12082093) ]. In mice, DCTN2 is involved in anchoring microtubules to centrosomes and may play a role in synapse formation during brain development [ (PUBMED:9144527) ].

GO process:microtubule-based process (GO:0007017)
GO component:dynactin complex (GO:0005869)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Dynamitin