The domain within your query sequence starts at position 54 and ends at position 82; the E-value for the EF-hand_1 domain shown below is 1.3e-7.



PFAM accession number:PF00036
Interpro abstract (IPR002048):

Many calcium-binding proteins belong to the same evolutionary family and share a type of calcium-binding domain known as the EF-hand. This type of domain consists of a twelve residue loop flanked on both sides by a twelve residue alpha-helical domain. In an EF-hand loop the calcium ion is coordinated in a pentagonal bipyramidal configuration. The six residues involved in the binding are in positions 1, 3, 5, 7, 9 and 12; these residues are denoted by X, Y, Z, -Y, -X and -Z. The invariant Glu or Asp at position 12 provides two oxygens for liganding Ca (bidentate ligand). Ca2 binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers [ (PUBMED:9228939) (PUBMED:8848832) (PUBMED:7553064) (PUBMED:7656053) (PUBMED:10591109) ].

GO function:calcium ion binding (GO:0005509)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry EF-hand_1