The domain within your query sequence starts at position 1 and ends at position 103; the E-value for the ER domain shown below is 9.9e-56.



PFAM accession number:PF01133
Interpro abstract (IPR000781):

The Drosophila protein 'enhancer of rudimentary' (gene (e(r)) is a small protein of 104 residues whose function is not yet clear. From an evolutionary point of view, it is highly conserved [ (PUBMED:9074495) ] and has been found to exist in probably all multicellular eukaryotic organisms. ERH has been implicated in the regulation of pyrimidine biosynthesis, DNA replication, transcription, mRNA splicing, cellular proliferation, tumorigenesis, and the Notch signaling pathway [ (PUBMED:27830090) ]. Fission yeast homologue of ERH is implicated in meiotic mRNA elimination during vegetative growth. It forms a stoichiometric complex with Mmi1 to promote meiotic mRNA decay and facultative heterochromatin assembly [ (PUBMED:26942678) (PUBMED:29424342) (PUBMED:31974447) ] in which the formation of ERH dimer is essential for the complex function.

ERH has been shown to interact with SAFB1/SAFB2 (scaffold attachment factor-B 1/2) at the nuclear matrix to regulate SR protein phosphorylation [ (PUBMED:28627136) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry ER