SMART: Pfam domain EphA2

The domain within your query sequence starts at position 421 and ends at position 496; the E-value for the EphA2_TM domain shown below is 2.4e-15.

VVVTVVTISALLVLGSVMSVLAIWRRPCDGKGSGNAHDEEELYFHFKVPTRRTFLDPQSC
GDPLQAVHLFAKELDA

EphA2_TM

PFAM accession number:	PF14575
Interpro abstract (IPR027936):	This entry represents the left-handed dimer transmembrane domain of Ephrin receptors. This domain oligomerises and is important for the active signalling process [ (PUBMED:20197042) ]. Proteins containing this domain include the ephrin type-A and type-B receptors. Ephrin receptors (Ephs) are a group of receptor tyrosine kinases that are activated in response to binding ephrin ligands residing on adjacent cells [ (PUBMED:12094214) ]. This binding leads to contact-dependent bidirectional signaling into neighbouring cells [ (PUBMED:12094214) ].

PFAM accession number:

PF14575

Interpro abstract (IPR027936):

This entry represents the left-handed dimer transmembrane domain of Ephrin receptors. This domain oligomerises and is important for the active signalling process [ (PUBMED:20197042) ].

Proteins containing this domain include the ephrin type-A and type-B receptors. Ephrin receptors (Ephs) are a group of receptor tyrosine kinases that are activated in response to binding ephrin ligands residing on adjacent cells [ (PUBMED:12094214) ]. This binding leads to contact-dependent bidirectional signaling into neighbouring cells [ (PUBMED:12094214) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry EphA2_TM