SMART: Pfam domain FAM176

The domain within your query sequence starts at position 252 and ends at position 392; the E-value for the FAM176 domain shown below is 5.8e-52.

DGVIVSNSLAAFAYIRAHPERAALLFMSSVCIGLLLTLCALVIRVSCTKDFRELRQGREH
LVLGSDKAEEDSEEDLEEEDSSDSQFPEELSRFCRTSYPAYSSIEAAELAERIERREQVI
QEIWMNSGLDSSLPRNVGHFY

FAM176

PFAM accession number:	PF14851
Interpro abstract (IPR039500):	This entry represents the EVA1 domain found in a group of proteins, including EVA1A/B/C. EVA1A, also known as TMEM166, regulates cell autophagy and apoptosis [ (PUBMED:17492404) (PUBMED:27490928) ]. This domain can be found in the C terminus of the human EVA1C, which serves as the Slit receptor that may mediate neural circuit formation in the developing nervous system. The EVA1C gene is located within the Down syndrome critical region (21q21-21q22.3) [ (PUBMED:24040182) ].

PFAM accession number:

PF14851

Interpro abstract (IPR039500):

This entry represents the EVA1 domain found in a group of proteins, including EVA1A/B/C. EVA1A, also known as TMEM166, regulates cell autophagy and apoptosis [ (PUBMED:17492404) (PUBMED:27490928) ].

This domain can be found in the C terminus of the human EVA1C, which serves as the Slit receptor that may mediate neural circuit formation in the developing nervous system. The EVA1C gene is located within the Down syndrome critical region (21q21-21q22.3) [ (PUBMED:24040182) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry FAM176