The domain within your query sequence starts at position 1 and ends at position 140; the E-value for the FA_FANCE domain shown below is 3.7e-56.



PFAM accession number:PF11510
Interpro abstract (IPR021025):

Fanconi Anaemia (FA) is a cancer predisposition disorder characterised by chromosome fragility and hypersensitivity to genotoxic agents that suggest defects in the molecular mechanisms of DNA damage signalling and repair. In response to DNA damage, the FA core complex monoubiquitinates the FANCD2 protein. This ubiquitination targets FANCD2 to nuclear foci where it interacts with a variety of DNA repair proteins.

The FA group E protein (FANCE) has an important role in DNA repair, functioning as the FANCD2-binding protein in the FA core complex [ (PUBMED:17308347) ]. This entry represents the C-terminal domain of FANCE, which consists predominantly of helices and does not contain any beta-strands. This domain folds in a continuous right-handed solenoidal pattern from its N terminus to its C terminus.

This is a PFAM domain. For full annotation and more information, please see the PFAM entry FA_FANCE