The domain within your query sequence starts at position 1 and ends at position 129; the E-value for the FancD2 domain shown below is 1.3e-62.



PFAM accession number:PF14631
Interpro abstract (IPR029448):

The Fanconi Anemia (FA) pathway is responsible for interstrand crosslink DNA repair [ (PUBMED:23444773) ]. The name originates the recessive syndrome known as Fanconi anemia, which causes developmental problems and cancer predisposition [ (PUBMED:11530803) ]. In this pathway, the FANCI-FANCD2 (ID) complex is ubiquitinated by the FA core complex and then travels to sites of damage to coordinate repair [ (PUBMED:20603016) (PUBMED:20603015) ]. FA pathway activation seems to trigger dissociation of FANCD2 from FANCI, coinciding with FANCD2 monoubiquitination which precedes monoubiquitination of FANCI [ (PUBMED:22753026) ]. This suggests a functional separation for FANCD2 from FANCI [ (PUBMED:23658231) ].

Monoubiquitinated FANCD2 functions to recruit DNA repair factors FAN1 (Fanconi-associated nuclease 1) [ (PUBMED:20603073) ] and SLX4 [ (PUBMED:21464321) ], suggesting that chromatin-bound FANCD2Ub is a docking platform for certain DNA repair nucleases. FANCD2 has also a role in replication fork recovery [ (PUBMED:24556218) ].

GO process:DNA repair (GO:0006281)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry FancD2