The domain within your query sequence starts at position 828 and ends at position 966; the E-value for the Focal_AT domain shown below is 2e-68.



PFAM accession number:PF03623
Interpro abstract (IPR005189):

Focal adhesion kinase (FAK) is a tyrosine kinase found in focal adhesions, intracellular signalling complexes that are formed following engagement of the extracellular matrix by integrins. The C-terminal "focal adhesion targeting" (FAT) region is necessary and sufficient for localizing FAK to focal adhesions. The crystal structure of FAT shows it forms a four-helix bundle that resembles those found in two other proteins involved in cell adhesion, alpha-catenin and vinculin [ (PUBMED:11799401) ]. The binding of FAT to the focal adhesion protein, paxillin, requires the integrity of the helical bundle, whereas binding to another focal adhesion protein, talin, does not.

GO process:protein phosphorylation (GO:0006468), signal complex assembly (GO:0007172)
GO component:focal adhesion (GO:0005925)
GO function:protein tyrosine kinase activity (GO:0004713)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Focal_AT