The domain within your query sequence starts at position 1 and ends at position 41; the E-value for the GED domain shown below is 5.9e-7.
LYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDI
GED |
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PFAM accession number: | PF02212 |
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Interpro abstract (IPR003130): | Dynamin GTPase effector domain found in proteins related to dynamin. Dynamin is a GTP-hydrolysing protein that is an essential participant in clathrin-mediated endocytosis by cells. It self-assembles into 'collars' in vivo at the necks of invaginated coated pits; the self-assembly of dynamin being coordinated by the GTPase domain. Mutation studies indicate that dynamin functions as a molecular regulator of receptor-mediated endocytosis [ (PUBMED:10206643) ]. |
GO function: | GTP binding (GO:0005525), GTPase activity (GO:0003924) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry GED