The domain within your query sequence starts at position 60 and ends at position 163; the E-value for the GILT domain shown below is 4e-33.



PFAM accession number:PF03227
Interpro abstract (IPR004911):

In humans, GILT (gamma-interferon-inducible lysosomal thiol reductase) functions in MHC class II-restricted antigen processing and MHC class I-restricted cross-presentation by reducing disulfide bonds of endocytosed proteins and facilitating their unfolding and optimal degradation [ (PUBMED:23246037) (PUBMED:21506690) ]. Several other functions of GILT have also been found, for instance, GILT can act as a host factor for Listeria monocytogenes infection and is involved in the maintenance of cellular glutathione (GSH) levels [ (PUBMED:23246037) ].

GILT is characterised by a CXXC motif in the active site and an enzymatic mechanism in which the pair of active site cysteine residues cooperate to reduce substrate disulfide bonds [ (PUBMED:23246037) ]. The GIL homologues from Drosophila melanogaster may play a role in the innate immune response upon bacterial challenge [ (PUBMED:24491521) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry GILT