The domain within your query sequence starts at position 1 and ends at position 84; the E-value for the GRAM domain shown below is 1.2e-19.



PFAM accession number:PF02893
Interpro abstract (IPR004182):

The GRAM domain is found in glucosyltransferases, myotubularins and other putative membrane-associated proteins. It is normally about 70 amino acids in length. It is thought to be an intracellular protein-binding or lipid-binding signalling domain, which has an important function in membrane-associated processes. The structure of the GRAM domain is similar to that found in PH domains [ (PUBMED:11050430) ]. Mutations in the GRAM domain of myotubularins cause a muscle disease, which suggests that the domain is essential for the full function of the enzyme [ (PUBMED:11050430) ]. Myotubularin-related proteins are a large subfamily of protein tyrosine phosphatases (PTPs) that dephosphorylate D3-phosphorylated inositol lipids [ (PUBMED:14690594) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry GRAM