The domain within your query sequence starts at position 646 and ends at position 753; the E-value for the GSAP-16 domain shown below is 6.8e-43.
LDLIWCLLETSWRKHSMHPLVLHLNSHCSAADFEVFHLMTRILDAASSLCLPLPPGFHSL HTILGVHCLPLYSLLHYIDNGVLLLTETAVTRLMKDLDNSEKNEQLKF
GSAP-16 |
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PFAM accession number: | PF14959 |
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Interpro abstract (IPR028010): | The gamma-secretase-activating protein (GSAP) family includes the mammalian GSAPs and the insect pigeon proteins (also known as linotte proteins). GSAP is a gamma-secretase regulator. It specifically activates the production of beta-amyloid protein through interactions with both gamma-secretase and its substrate, the amyloid precursor protein carboxy-terminal fragment (APP-CTF) [ (PUBMED:20811458) ]. This has led to interest in the protein as potential therapeutic target for the treatment of Alzheimer's disease [ (PUBMED:20811458) ]. Pigeon/linotte was initially identified as a gene that functions in adult Drosophila during associative learning [ (PUBMED:7576632) ]. This entry represents a domain found in the C-terminal of GSAP family members. |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry GSAP-16