The domain within your query sequence starts at position 340 and ends at position 595; the E-value for the Glyco_hydro_2_C domain shown below is 3.8e-12.



PFAM accession number:PF02836
Interpro abstract (IPR006103):

O-Glycosyl hydrolases ( EC 3.2.1. ) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [ (PUBMED:7624375) (PUBMED:8535779) ]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) website.

Glycoside hydrolase family 2 comprises enzymes with several known activities; beta-galactosidase ( EC ); beta-mannosidase ( EC ); beta-glucuronidase ( EC ).

These enzymes contain a conserved glutamic acid residue which has been shown [ (PUBMED:1350782) ], in Escherichia coli lacZ ( P00722 ), to be the general acid/base catalyst in the active site of the enzyme.

Beta-galactosidase from E. coli has a TIM-barrel-like core surrounded by four other largely beta domains [ (PUBMED:8008071) ].

GO process:carbohydrate metabolic process (GO:0005975)
GO function:hydrolase activity, hydrolyzing O-glycosyl compounds (GO:0004553)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Glyco_hydro_2_C