The domain within your query sequence starts at position 26 and ends at position 677; the E-value for the Granin domain shown below is 8.1e-238.
RDHNEEMVTRCIIEVLSNALSKSSVPTITPECRQVLKKSGKEVKGEEKGENQNSKFEVRL LRDPADASGTRWASSREDAGAPVEDSQGQTKVGNEKWTEGGGHSREGVDDQESLRPSNQQ ASKEAKIYHSEERVGKEREKEEGKIYPMGEHREDAGEEKKHIEDSGEKPNTFSNKRSEAS AKKKDESVARADAHSMELEEKTHSREQSSQESGEETRRQEKPQELTDQDQSQEESQEGEE GEEGEEGEEGEEDSASEVTKRRPRHHHGRSGSNKSSYEGHPLSEERRPSPKESKEADVAT VRLGEKRSHHLAHYRASEEEPEYGEESRSYRGLQYRGRGSEEDRAPRPRSEESQEREYKR NHPDSELESTANRHGEETEEERSYEGANGRQHRGRGREPGAHSALDTREEKRLLDEGHYP VRESPIDTAKRYPQSKWQEQEKNYLNYGEEGDQGRWWQQEEQLGPEESREEVRFPDRQYE PYPITEKRKRLGALFNPYFDPLQWKNSDFEKRGNPDDSFLEDEGEDRNGVTLTEKNSFPE YNYDWWERRPFSEDVNWGYEKRSFARAPQLDLKRQYDGVAELDQLLHYRKKADEFPDFYD SEEQMGPHQEANDEKARADQRVLTAEEKKELENLAAMDLELQKIAEKFSQRG
Granin |
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PFAM accession number: | PF01271 |
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Interpro abstract (IPR001990): | Granins (chromogranins or secretogranins) [ (PUBMED:2053134) ] are a family of acidic proteins present in the secretory granules of a wide variety of endocrine and neuro-endocrine cells. The exact function(s) of these proteins is not yet known but they seem to be the precursors of biologically active peptides and/or they may act as helper proteins in the packaging of peptide hormones and neuropeptides. Apart from their subcellular location and the abundance of acidic residues (Asp and Glu), these proteins do not share many structural similarities. Only one short region, located in the C-terminal section, is conserved in all these proteins, such as:
Chromogranins and secretogranins together share a C-terminal motif, whereas chromogranins A and B share a region of high similarity in their N-terminal section; this region includes two cysteine residues involved in a disulphide bond. |
GO component: | secretory granule (GO:0030141) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry Granin