The domain within your query sequence starts at position 47 and ends at position 130; the E-value for the Guanylin domain shown below is 2.4e-33.



PFAM accession number:PF02058
Interpro abstract (IPR000879):

This entry represents the guanylin family. Its members include guanylate cyclase activator 2A and 2B. They are endogenous activators of intestinal guanylate cyclases.

Guanylin, a 15-amino-acid peptide, is an endogenous ligand of the intestinal receptor guanylate cyclase-C, known as STaR [ (PUBMED:7713512) (PUBMED:1409606) ]. Upon receptor binding, guanylin increases the intracellular concentration of cGMP, it induces chloride secretion and decreases intestinal fluid absorption, ultimately causing diarrhoea [ (PUBMED:1346555) ]. The peptide stimulates the enzyme through the same receptor binding region as the heat-stable enterotoxins [ (PUBMED:1409606) ].

GO component:extracellular region (GO:0005576)
GO function:guanylate cyclase activator activity (GO:0030250)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Guanylin