The domain within your query sequence starts at position 446 and ends at position 852; the E-value for the HAD domain shown below is 2.4e-14.

LLTDKTGTLTQNEMVFKRLHLGTVAYGLDSMDEVQSHIFSIYTQQSQDPPAQKGPTVTTK
VRRTMSSRVHEAVKAIALCHNVTPVYESNGVTDQAEAEKQFEDSCRVYQASSPDEVALVQ
WTESVGLTLVGRDQSSMQLRTPGDQVLNLTILQVFPFTYESKRMGIIVRDESTGEITFYM
KGADVVMAGIVQYNDWLEEECGNMAREGLRVLVVAKKSLTEEQYQDFEARYVQAKLSVHD
RSLKVATVIESLEMEMELLCLTGVEDQLQADVRPTLETLRNAGIKVWMLTGDKLETATCT
AKNAHLVTRNQDIHVFRLVTNRGEAHLELNAFRRKHDCALVISGDSLEVCLKYYEYEFME
LACQCPAVVCCRCAPTQKAQIVRLLQERTGKLTCAVGDGGNDVSMIQ

HAD

 HAD
PFAM accession number:

This is a PFAM domain. For full annotation and more information, please see the PFAM entry HAD