The domain within your query sequence starts at position 101 and ends at position 226; the E-value for the HEXIM domain shown below is 1.1e-49.



PFAM accession number:PF15313
Interpro abstract (IPR024872):

Hexamethylene bisacetamide-inducible proteins (HEXIMs) are transcriptional regulators that function as general RNA polymerase II transcription inhibitors. HEXIMs, aided by the 7SK snRNA, sequester positive transcriptional elongation factor b (P-TEFb) into a large inactive 7SK snRNP complex [ (PUBMED:14580347) (PUBMED:15713661) ]. This prevents P-TEFb from phosphorylating RNA polymerase II and blocks subsequent transcriptional elongation.

Two HEXIM family members have been identified in mammals, termed HEXIM1 and HEXIM2, which exhibit distinct expression patterns [ (PUBMED:15713661) ].

GO process:negative regulation of transcription by RNA polymerase II (GO:0000122)
GO component:nucleus (GO:0005634), cytoplasm (GO:0005737)
GO function:cyclin-dependent protein serine/threonine kinase inhibitor activity (GO:0004861), snRNA binding (GO:0017069)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry HEXIM