The domain within your query sequence starts at position 193 and ends at position 220; the E-value for the HS1_rep domain shown below is 2.1e-14.



PFAM accession number:PF02218
Interpro abstract (IPR003134):

The cortactin or HS1 repeat is a tandem repeat of 37-amino acid actin-binding domains. The repeat is named after human cortactin and HS1, proteins involved in cytoskeletal rearrangements implicated in cell migration and apoptosis, respectively. Cortactin contains 6.5 tandem copies of the repeat and is conserved among metazoans, although e.g. insect cortactin and splice variants contain fewer copies. Hematopoietic lineage cell specific protein 1 (HS1) contains 3.5 tandem copies of the cortactin repeat and is mainly expressed in hematopoietic cells. Both cortactin and HS1 contain a C-terminal SH3 domain ( IPR001452 ). The cortactin repeat domain binds filamentous actin (F-actin) in proteins that modulate the assembly of the actin cytoskeleton. Secondary structure predictions indicate that the cortactin repeat could exhibit a helix-turn-helix structure [ (PUBMED:12534372) (PUBMED:15186216) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry HS1_rep