The domain within your query sequence starts at position 129 and ends at position 223; the E-value for the IL6Ra-bind domain shown below is 5.2e-23.
GAENLTCEIRAARFLSCAWREGPAAPADVRYSLRVLNSTGHDVARCMADPGDDVITQCIA NDLSLLGSEAYLVVTGRSGAGPVRFLDDVVATKAL
IL6Ra-bind |
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PFAM accession number: | PF09240 |
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Interpro abstract (IPR015321): | The alpha chain of the interleukin-6 receptor (IL-6R-alpha) consists of a signal peptide, an extracellular region, a transmembrane domain, and a short cytoplasmic domain. The extracellular region is highly modular, consisting of three domains (D1, D2, and D3). The N-terminal domain D1 is characteristic of the Ig superfamily, and domains D2 and D3 are homologous to cytokine-binding domains (CBD) consisting of two fibronectin type III (FnIII) domains [ (PUBMED:2169613) (PUBMED:12461182) ]. This domain corresponds to the D2 domain in IL-6R-alpha and is also found in other members of the type I cytokine receptor family. |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry IL6Ra-bind