The domain within your query sequence starts at position 114 and ends at position 319; the E-value for the Ion_trans domain shown below is 1.4e-22.



PFAM accession number:PF00520
Interpro abstract (IPR005821):

This domain is found in sodium, potassium, and calcium ion channels proteins. The proteins have 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some Na channel proteins the domain is repeated four times, whereas in others (e.g. K channels) the protein forms a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not included in the Pfam family due to it lacking the first four helices.

GO process:transmembrane transport (GO:0055085), ion transport (GO:0006811)
GO component:membrane (GO:0016020)
GO function:ion channel activity (GO:0005216)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Ion_trans