The domain within your query sequence starts at position 737 and ends at position 839; the E-value for the KCNQC3-Ank-G_bd domain shown below is 1.6e-51.



PFAM accession number:PF11956
Interpro abstract (IPR020969):

Interactions with ankyrin-G are crucial to the localisation of voltage-gated sodium channels (VGSCs) at the axon initial segment and for neurons to initiate action potentials. This conserved 9-amino acid motif ((V/A)P(I/L)AXXE(S/D)D) is required for ankyrin-G binding and functions to localise sodium channels to a variety of 'excitable' membrane domains both inside and outside of the nervous system [ (PUBMED:12716895) ]. This motif has also been identified in the potassium channel 6TM proteins KCNQ2 and KCNQ3 [ (PUBMED:16525039) ] that correspond to the M channels that exert a crucial influence over neuronal excitability. KCNQ2/KCNQ3 channels are preferentially localised to the surface of axons both at the axonal initial segment and more distally, and this axonal initial segment targeting of surface KCNQ channels is mediated by these ankyrin-G binding motifs of KCNQ2 and KCNQ3 [ (PUBMED:16735477) ]. KCNQ3 is a major determinant of M channel localisation to the AIS, rather than KCNQ2 [ (PUBMED:17311847) ]. Phylogenetic analysis reveals that anchor motifs evolved sequentially in chordates (NaV channel) and jawed vertebrates (KCNQ2/3) [ (PUBMED:19112491) ].

GO component:membrane (GO:0016020)
GO function:potassium channel activity (GO:0005267)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry KCNQC3-Ank-G_bd