The domain within your query sequence starts at position 41 and ends at position 382; the E-value for the MIIP domain shown below is 1.4e-142.
GSNLDCSSNNLEMPLSQETSSASSVAPSSQDKRHMLDPLDSRRDDTFDVAWYVKFNSRMD SFLPATGQHQEPQEELRPPSVPLLATQGLKGPVSLGGPKGLGPDKTQVPRSILSRLSKPS KPRVTSQESAVPESSWHSRPYLGYDWIAGSLDNSSPVTSEPEAFFSMLQRFRENNKEDCV CNSPEAVFPGLQESSGVEEDHECMYCYRINRRLFPEPVDPGAPCRLCGIPRDEKGPGTLV EPVQVRVSIPLSIMDPPHQYRIHRRKSFDASDTLALPRHCLLGWDILPPKSEKTSVPKSL DLWSSVSYGAGQRRDLSATSPPCQKPRGQTAQKTTVFYQCQQ
MIIP |
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PFAM accession number: | PF15734 |
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Interpro abstract (IPR031466): | Migration and invasion-inhibitory protein (MIIP or IIp45) binds to insulin-like growth factor binding protein 2 (IGFBP-2) and inhibits the invasion of glioma cells [ (PUBMED:14617774) ]. MIIP attenuates mitotic transition, thereby inhibiting glioma progression [ (PUBMED:20418911) ]. It not only modulates IGFBP-2, but also inhibits cell migration by binding to and inhibiting HDAC6, a class 2 histone deacetylase that deacetylates alpha-tubulin [ (PUBMED:20008322) ]. |
GO process: | negative regulation of G2/M transition of mitotic cell cycle (GO:0010972), negative regulation of cell migration (GO:0030336) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry MIIP