The domain within your query sequence starts at position 467 and ends at position 542; the E-value for the MKRN1_C domain shown below is 1.3e-11.



PFAM accession number:PF15815
Interpro abstract (IPR031644):

This domain is found at the C terminus of makorins, a family of eukaryotic putative ribonucleoproteins with a distinctive array of zinc-finger motifs [ (PUBMED:10843807) ]. Makorin-1 (MKRN1) plays an important role in modulating the homeostasis of telomere-length through a dynamic balance involving the stability of the protein hTERT [ (PUBMED:15805468) ]. MKRN1 has been shown to be a a transcriptional co-regulator and an E3 ligase. It functions simultaneously as a differentially negative regulator of p53 and p21, preferentially leading cells to p53-dependent apoptosis by suppressing p21 [ (PUBMED:19536131) ]. The exact function of the C-terminal region has not been determined.

This is a PFAM domain. For full annotation and more information, please see the PFAM entry MKRN1_C