SMART: Pfam domain MSL1

The domain within your query sequence starts at position 216 and ends at position 252; the E-value for the MSL1_dimer domain shown below is 5e-22.

GASSQAACLKQILLLQLDLIEQQQQQLQAKEKEIEEL

MSL1_dimer

PFAM accession number:	PF16801
Interpro abstract (IPR031840):	This entry represents the short coiled dimerisation domain of higher eukaryotic MSL1, part of the MSL or Male-Specific Lethal complex. This complex regulates the dosage compensation of the male X chromosome in Drosophila and other eukaryotes. The structure of the MSL1/MSL2 core shows that two MSL2 subunits bind to a dimer formed by two molecules of MSL1. MSL1 is a substrate for MSL2 E3 ubiquitin ligase activity [ (PUBMED:23084835) ].

PFAM accession number:

PF16801

Interpro abstract (IPR031840):

This entry represents the short coiled dimerisation domain of higher eukaryotic MSL1, part of the MSL or Male-Specific Lethal complex. This complex regulates the dosage compensation of the male X chromosome in Drosophila and other eukaryotes. The structure of the MSL1/MSL2 core shows that two MSL2 subunits bind to a dimer formed by two molecules of MSL1. MSL1 is a substrate for MSL2 E3 ubiquitin ligase activity [ (PUBMED:23084835) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry MSL1_dimer