The domain within your query sequence starts at position 1803 and ends at position 2029; the E-value for the Med12-PQL domain shown below is 2.3e-14.



PFAM accession number:PF12144
Interpro abstract (IPR021989):

This domain is found in eukaryotes, and is typically between 325 and 354 amino acids in length. It is found in the C-terminal region of the mediator of RNA polymerase II transcription subunit 12. Both development and carcinogenesis are driven by signal transduction within the canonical Wnt/beta-catenin pathway through both programmed and unprogrammed changes in gene transcription. Beta-catenin physically and functionally targets this PQL (proline-, glutamine-, leucine-rich) region of the Med12 subunit of Mediator to activate transcription. The beta-catenin transactivation domain binds directly to isolated Med12 and intact Mediator both in vitro and in vivo, and Mediator is recruited to Wnt-responsive genes in a beta-catenin-dependent manner.

GO component:mediator complex (GO:0016592)
GO function:beta-catenin binding (GO:0008013)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Med12-PQL