The domain within your query sequence starts at position 161 and ends at position 237; the E-value for the Methyltransf_4 domain shown below is 7.1e-5.



PFAM accession number:PF02390
Interpro abstract (IPR003358):

This entry represents tRNA (guanine-N-7) methyltransferase ( EC ), which catalyses the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. Capping of the pre-mRNA 5' end by addition a monomethylated guanosine cap (m(7)G) is an essential and the earliest modification in the biogenesis of mRNA [ (PUBMED:17949828) ]. The reaction is catalysed by three enzymes: triphosphatase, guanylyltransferase, and tRNA (guanine-N-7) methyltransferase [ (PUBMED:12403464) (PUBMED:18412263) ]. This entry includes Bacillus subtilis TrmB, which contains a a unique variant of the Rossmann-fold methyltransferase (RFM) structure, with the N-terminal helix folded on the opposite site of the catalytic domain [ (PUBMED:16600901) ].

Methyltransferases (EC 2.1.1.-) constitute an important class of enzymes present in every life form. They transfer a methyl group most frequently from S-adenosyl L-methionine (SAM or AdoMet) to a nucleophilic acceptor such as oxygen leading to S-adenosyl-L-homocysteine (AdoHcy) and a methylated molecule [ (PUBMED:16225687) (PUBMED:21858014) (PUBMED:12826405) ]. All these enzymes have in common a conserved region of about 130 amino acid residues that allow them to bind SAM [ (PUBMED:7897657) ]. The substrates that are methylated by these enzymes cover virtually every kind of biomolecules ranging from small molecules, to lipids, proteins and nucleic acids [ (PUBMED:16225687) (PUBMED:21858014) (PUBMED:7897657) ]. Methyltransferase are therefore involved in many essential cellular processes including biosynthesis, signal transduction, protein repair, chromatin regulation and gene silencing [ (PUBMED:16225687) (PUBMED:21858014) (PUBMED:12826405) ]. More than 230 families of methyltransferases have been described so far, of which more than 220 use SAM as the methyl donor.

GO process:tRNA modification (GO:0006400)
GO function:tRNA (guanine-N7-)-methyltransferase activity (GO:0008176)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Methyltransf_4