The domain within your query sequence starts at position 1 and ends at position 345; the E-value for the Myc_N domain shown below is 1.4e-141.
MPLNVNFTNRNYDLDYDSVQPYFICDEEENFYHQQQQSELQPPAPSEDIWKKFELLPTPP LSPSRRSGLCSPSYVAVATSFSPREDDDGGGGNFSTADQLEMMTELLGGDMVNQSFICDP DDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSTSLSPARGHSVCSTSSLYLQ DLTAAASECIDPSVVFPYPLNDSSSPKSCTSSDSTAFSPSSDSLLSSESSPRASPEPLVL HEETPPTTSSDSEEEQEDEEEIDVVSVEKRQTPAKRSESGSSPSRGHSKPPHSPLVLKRC HVSTHQHNYAAPPSTRKDYPAAKRAKLDSGRVLKQISNNRKCSSP
Myc_N |
---|
PFAM accession number: | PF01056 |
---|---|
Interpro abstract (IPR012682): | The class III basic helix-turn-helix (bHLH) transcription factors have proliferative and apoptotic roles and are characterised by the presence of a leucine zipper adjacent to the bHLH domain. The myc oncogene gene was first discovered in small-cell lung cancer cell lines where it is found to be deregulated [ (PUBMED:2827002) ]. Although the biochemical function of the gene product is unknown, as a nuclear protein with a short half-life it may play a direct or indirect role in controlling gene expression [ (PUBMED:3018999) ]. Myc forms a heterodimer with Max, and this complex regulates cell growth through direct activation of genes involved in cell replication [ (PUBMED:9175477) ]. This entry represents the N-terminal domain found adjacent to the basic helix-loop-helix (bHLH) region ( IPR011598 ). |
GO process: | regulation of transcription, DNA-templated (GO:0006355) |
GO function: | DNA-binding transcription factor activity (GO:0003700) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry Myc_N